CAJ | 학술논문

　　目的探讨姜黄素联合阿霉素对人膀胱癌T24细胞的生长抑制及其诱导肿瘤凋亡的协同作用．方法用不同浓度的姜黄素和阿霉素分别及联合作用T24细胞，用MTT法检测细胞增殖抑制率，流式细胞仪检测细胞凋亡和细胞周期分布．结果阿霉素和姜黄素联用时，能较大幅度增强姜黄素的抑制效果（P＜0．05）；流式细胞仪检测结果显示：姜黄素与阿霉素联合将细胞周期阻滞于S期．结论姜黄素联合阿霉素对膀胱癌细胞T24的生长有协同抑制效应，能提高阿霉素对人膀胱癌T24细胞的敏感性．
　　목적탐토강황소연합아매소대인방광암T24세포적생장억제급기유도종류조망적협동작용．방법용불동농도적강황소화아매소분별급연합작용T24세포，용MTT법검측세포증식억제솔，류식세포의검측세포조망화세포주기분포．결과아매소화강황소련용시，능교대폭도증강강황소적억제효과（P＜0．05）；류식세포의검측결과현시：강황소여아매소연합장세포주기조체우S기．결론강황소연합아매소대방광암세포T24적생장유협동억제효응，능제고아매소대인방광암T24세포적민감성．
Objective To study the synergistic inhibition of curcumin in combination with adriamycin on bladder cancer cell line T24 and the synergistic induction of it on the apoptosis of bladder cancer cell line T 24.Method MTT assay was used to detect the proliferation inhibition rate of T 24 cells treated with different concentrations of the curcumin or adriamycin or curcumin in combination with adriamycin respectively ,and the apoptosis and the distribution of cell cycle was detected with a flow cytometer .Results The combined application of curcumin with adriamycin could significantly improve the inhibitory effect of curcumin alone ( P<0 .05 ) .The results with flow cytometry suggested that T24 cells were arrested at S phase .Conclusion The combined application of curcumin with adriamycin can produce a synergistic inhibitory effect on T 24 cells,which may improve the sensitivity of T 24 cells to adriamycin .