CAJ | 학술논문

　　目的研究磁共振波谱成像技术在中枢神经系统疾病诊断中的临床应用效果。方法采用对比分析法、资料文献分析法、问卷调查等方法对磁共振波谱成像技术的应用效果进行分析。结果我院研究资料显示，脑出血患者迟发性水肿区的磁共振波谱区乳酸（Lac）峰数值发生改变，N-乙酰天门冬氨酸与肌酸的比值（NAA/Cr）出现下降，说明此区域严重缺血且神经元已受到损伤；以大鼠作为实验对象的脑梗死研究结果表明NAA数值随着时间的增长而不断下降至消失；帕金森患者诊断结果显示对照组患者黑质区中的海马NAA/Cr明显高于实验组；磁共振波谱成像技术能够较早地发现阿尔茨海默病的病理改变情况；多发性硬化疾病诊断结果表明患者的NAA值降低， NAA/Cr呈下降趋势。结论在临床实践中，采用磁共振波谱技术可以对脑血管疾病患者与中枢神经变性疾病患者的病情做出及时诊断，及时制定治疗方案，提高诊断率。
　　목적연구자공진파보성상기술재중추신경계통질병진단중적림상응용효과。방법채용대비분석법、자료문헌분석법、문권조사등방법대자공진파보성상기술적응용효과진행분석。결과아원연구자료현시，뇌출혈환자지발성수종구적자공진파보구유산（Lac）봉수치발생개변，N-을선천문동안산여기산적비치（NAA/Cr）출현하강，설명차구역엄중결혈차신경원이수도손상；이대서작위실험대상적뇌경사연구결과표명NAA수치수착시간적증장이불단하강지소실；파금삼환자진단결과현시대조조환자흑질구중적해마NAA/Cr명현고우실험조；자공진파보성상기술능구교조지발현아이자해묵병적병리개변정황；다발성경화질병진단결과표명환자적NAA치강저， NAA/Cr정하강추세。결론재림상실천중，채용자공진파보기술가이대뇌혈관질병환자여중추신경변성질병환자적병정주출급시진단，급시제정치료방안，제고진단솔。
Objective To investigate the clinical effect of magnetic resonance spectroscopic imaging technique in diagnosis of central nervous system disease. Methods Using comparative analysis, literature analysis, and questionnaire survey to analyze the research data. Results Lactic acid peak value of magnetic resonance spectroscopy region in delayed edema area of patients with cerebral hemorrhage was changed and NAA/Cr value was decreased, which indicated that this region was of severe ischemia and neurons had been damaged. Results of cerebral infarction research which used rats as experimental objects showed that NAA value was declined constantly and finally disappeared as time extended. Diagnostic results of patients with Parkinson's disease showed that hippocampal NAA/Cr value in substantia nigra of control group was much higher than that of experimental group. Pathological changes of Alzheimer's disease can be found timely by using magnetic resonance spectroscopic imaging technique. Diagnostic results of patients with MS's diseases showed that NAA value had been decreased. Conclusion The condition of patients with cerebrovascular and neural degeneration diseases can be determined timely by using magnetic resonance spectroscopy so that patients can get timely diagnosis and treatment.