中国组织工程研究
中國組織工程研究
중국조직공정연구
Journal of Clinical Rehabilitative Tissue Engineering Research
2014年
44期
7077-7082
,共6页
张波%赵金龙%欧阳振%于洋%吴涛%宋永才%李伍健%刘继超%尹伟%杨立峰%刘丰虎%杨斌辉
張波%趙金龍%歐暘振%于洋%吳濤%宋永纔%李伍健%劉繼超%尹偉%楊立峰%劉豐虎%楊斌輝
장파%조금룡%구양진%우양%오도%송영재%리오건%류계초%윤위%양립봉%류봉호%양빈휘
植入物%骨植入物%低毒性感染%窦道形成%骨折术后%利福平%环丙沙星%皮瓣转移%治疗
植入物%骨植入物%低毒性感染%竇道形成%骨摺術後%利福平%環丙沙星%皮瓣轉移%治療
식입물%골식입물%저독성감염%두도형성%골절술후%리복평%배병사성%피판전이%치료
背景：近年国内外对骨折内固定后低毒性感染的报道有较多的文献，但对术后慢性低毒性感染内固定取出是否是必须的报道不一，没有固定的疗效判断标准，导致治疗方法结论不确切。<br> 目的：观察口服利福平、环丙沙星加皮瓣转移对胫骨平台及踝部骨折内外固定后低毒性感染伴窦道形成的疗效。<br> 方法：收集2005年9月至2012年12月收治的胫骨平台及踝部骨折内外固定后低毒性感染患者56例，其中治疗组30例采用口服环丙沙星+利福平+皮瓣转移治疗，对照组26例采用常规静点抗生素+局部清创内固定取出治疗。两组均完成3-6个月的疗程，每1-3个月复查血沉、肝肾功及影像学指标评估疗效。<br> 结果与结论：随访6-24个月，治愈、好转患者无复发。治疗组24例治愈，4例好转，2例无效，总有效率为93%；对照组11例治愈，6例好转，无效9例，总有效率为65%。经χ2检验，治疗组疗效明显优于对照组(P<0.05)。提示口服利福平、环丙沙星加皮瓣转移对胫骨平台及踝部骨折内外固定后低毒性感染伴窦道形成有良好的修复效果。
揹景：近年國內外對骨摺內固定後低毒性感染的報道有較多的文獻，但對術後慢性低毒性感染內固定取齣是否是必鬚的報道不一，沒有固定的療效判斷標準，導緻治療方法結論不確切。<br> 目的：觀察口服利福平、環丙沙星加皮瓣轉移對脛骨平檯及踝部骨摺內外固定後低毒性感染伴竇道形成的療效。<br> 方法：收集2005年9月至2012年12月收治的脛骨平檯及踝部骨摺內外固定後低毒性感染患者56例，其中治療組30例採用口服環丙沙星+利福平+皮瓣轉移治療，對照組26例採用常規靜點抗生素+跼部清創內固定取齣治療。兩組均完成3-6箇月的療程，每1-3箇月複查血沉、肝腎功及影像學指標評估療效。<br> 結果與結論：隨訪6-24箇月，治愈、好轉患者無複髮。治療組24例治愈，4例好轉，2例無效，總有效率為93%；對照組11例治愈，6例好轉，無效9例，總有效率為65%。經χ2檢驗，治療組療效明顯優于對照組(P<0.05)。提示口服利福平、環丙沙星加皮瓣轉移對脛骨平檯及踝部骨摺內外固定後低毒性感染伴竇道形成有良好的脩複效果。
배경：근년국내외대골절내고정후저독성감염적보도유교다적문헌，단대술후만성저독성감염내고정취출시부시필수적보도불일，몰유고정적료효판단표준，도치치료방법결론불학절。<br> 목적：관찰구복리복평、배병사성가피판전이대경골평태급과부골절내외고정후저독성감염반두도형성적료효。<br> 방법：수집2005년9월지2012년12월수치적경골평태급과부골절내외고정후저독성감염환자56례，기중치료조30례채용구복배병사성+리복평+피판전이치료，대조조26례채용상규정점항생소+국부청창내고정취출치료。량조균완성3-6개월적료정，매1-3개월복사혈침、간신공급영상학지표평고료효。<br> 결과여결론：수방6-24개월，치유、호전환자무복발。치료조24례치유，4례호전，2례무효，총유효솔위93%；대조조11례치유，6례호전，무효9례，총유효솔위65%。경χ2검험，치료조료효명현우우대조조(P<0.05)。제시구복리복평、배병사성가피판전이대경골평태급과부골절내외고정후저독성감염반두도형성유량호적수복효과。
BACKGROUND:Recently, there are many documents al over the world reporting hypotoxicity infection after fracture internal fixation surgery, but reports are different on whether it is necessary for chronic hypotoxicity infection internal fixation removal post surgery. There are no fixed judgment criteria of curative effects, which leads to inexact conclusion of treatment method. <br> OBJECTIVE:To observe the curative effects of taking rifampicin and ciprofloxacin with transfer of skin flap in the treatment of chronic hypotoxicity infection with sinus formation after fracture surgery on tibial plateau and ankle. METHODS:A total of 56 cases of chronic hypotoxicity infection after fracture surgery of tibial plateau and ankle were col ected from September 2005 to December 2012. 30 cases in the therapy group were treated with <br> levofloxacin and rifampicin with transfer of skin flap. 26 cases in the control group were treated with conventional intravenous antibiotics with local debridement to remove internal fixation. In both groups, the course of disease was 3 to 6 months. The erythrocyte sedimentation rate, kidney function and radiographic indices were reviewed every 1 to 3 months, and curative effects were evaluated. <br> RESULTS AND CONCLUSION:During the fol ow-up visit of 6-24 months, no recurrence happened to the cured and improved patients. In the therapy group, 24 cases were cured, 4 cases were improved, and 2 cases were invalid, with a total effective rate of 93%. In the control group, 11 cases were cured, 6 cases were improved and 9 cases were invalid with the total effective rate of 65%.χ2 test showed that therapeutic effects were significantly better in the therapy group than in the control group (P<0.05). These data indicated that rifampicin and ciprofloxacin with transfer of skin flap for chronic hypotoxicity infection with sinus formation after fracture surgery of tibial plateau and ankle showed good curative effects.
