江汉大学学报(自然科学版)
江漢大學學報(自然科學版)
강한대학학보(자연과학판)
JOURNAL OF JIANGHAN UNIVERSITY(NATURAL SCIENCES)
2014年
5期
46-49
,共4页
慢性阻塞性肺疾病%贫血%炎症%IL-6%IL-8%TNF-α%CD4+/CD8+
慢性阻塞性肺疾病%貧血%炎癥%IL-6%IL-8%TNF-α%CD4+/CD8+
만성조새성폐질병%빈혈%염증%IL-6%IL-8%TNF-α%CD4+/CD8+
chronic obstructive pulmonary disease(COPD)%anemia%inflammation%IL-6%IL-8%TNF-α%CD4+/CD8+
目的:研究慢性阻塞性肺疾病(COPD)合并贫血患者与炎症的关系。方法根据贫血标准对273例慢性阻塞性肺疾病急性加重期(AECOPD)患者进行调查,对其中合并贫血的COPD患者(贫血组)40例和非贫血的COPD患者(非贫血组)40例为研究对象。常规行肺功能(FEV1%)检查,测定血清细胞因子白细胞介质IL-6、IL-8与肿瘤坏死因子-α(TNF-α)及流式细胞仪检测CD4+、CD8+T细胞,并计算其相关性。结果贫血组患者的炎症指标IL-6、IL-8、TNF-α水平高于非贫血组(P<0.05),CD4+/CD8+T细胞比例低于非贫血组(P<0.05),差异均有统计学意义。结论 COPD患者合并贫血可能与炎症相关。
目的:研究慢性阻塞性肺疾病(COPD)閤併貧血患者與炎癥的關繫。方法根據貧血標準對273例慢性阻塞性肺疾病急性加重期(AECOPD)患者進行調查,對其中閤併貧血的COPD患者(貧血組)40例和非貧血的COPD患者(非貧血組)40例為研究對象。常規行肺功能(FEV1%)檢查,測定血清細胞因子白細胞介質IL-6、IL-8與腫瘤壞死因子-α(TNF-α)及流式細胞儀檢測CD4+、CD8+T細胞,併計算其相關性。結果貧血組患者的炎癥指標IL-6、IL-8、TNF-α水平高于非貧血組(P<0.05),CD4+/CD8+T細胞比例低于非貧血組(P<0.05),差異均有統計學意義。結論 COPD患者閤併貧血可能與炎癥相關。
목적:연구만성조새성폐질병(COPD)합병빈혈환자여염증적관계。방법근거빈혈표준대273례만성조새성폐질병급성가중기(AECOPD)환자진행조사,대기중합병빈혈적COPD환자(빈혈조)40례화비빈혈적COPD환자(비빈혈조)40례위연구대상。상규행폐공능(FEV1%)검사,측정혈청세포인자백세포개질IL-6、IL-8여종류배사인자-α(TNF-α)급류식세포의검측CD4+、CD8+T세포,병계산기상관성。결과빈혈조환자적염증지표IL-6、IL-8、TNF-α수평고우비빈혈조(P<0.05),CD4+/CD8+T세포비례저우비빈혈조(P<0.05),차이균유통계학의의。결론 COPD환자합병빈혈가능여염증상관。
Objective To study the relation between the chronic obstructive pulmonary disease (COPD )with anemia and inflammation. Methods According to the anemia standard,the 273 cas?es of AECOPD were enrolled. 40 cases of anemia in COPD(anemia group)and 40 cases of non-ane?mic in COPD(non-anemia group) were selected. Lung function(FEV1%),and interleukin-6 (IL-6),interleukin-8(IL-8),and tumor necrosis factor-α(TNF-α)were determined,and the count of CD4+and CD8+T cell were measured with flow cytometry. The correlation was studied. Re?sults The level of interleukin-6(IL-6),interleukin-8(IL-8),and tumor necrosis factor-α(TNF-α)were significantly higher in anemia group than in non-anemic group(P< 0.05). The ratio of CD4+/CD8+ in anemia group were significantly lower than non-anemic group(P< 0.05). Conclu?sion COPD with anemic may be related inflammation.