中国基层医药
中國基層醫藥
중국기층의약
CHINESE JOURNAL OF PRIMARY MEDICINE AND PHARMACY
2014年
8期
1129-1131
,共3页
钟萍萍%顾依群%王军%周秋立%王爱春
鐘萍萍%顧依群%王軍%週鞦立%王愛春
종평평%고의군%왕군%주추립%왕애춘
DNA指数%DNA定量分析%宫颈肿瘤
DNA指數%DNA定量分析%宮頸腫瘤
DNA지수%DNA정량분석%궁경종류
DNA index%Quantitative DNA cytology%Cervical neoplasms
目的 比较DNA定量分析与薄层液基细胞学(TCT)检查在宫颈癌中的应用价值,以提高细胞学诊断的准确性.方法 对7 470例妇女行宫颈薄层液基细胞学(TCT)及DNA定量分析,结果异常者用二代基因杂交捕获法(HC2)检测高危型人乳头状瘤病毒(HPV),TCT在ASC及以上病变为阳性,DNA指数≥2.5为阳性.结果 7470例患者,用DNA定量分析法检测阳性率为13.0%,TCT检查阳性率为13.7%,两种检查方法差异无统计学意义(x2 =1.813,P=0.178);≥3个细胞2.5≤DNA指数<4.5者及DNA指数≥4.5者的TCT阳性率明显高于<3个细胞2.5≤DNA指数<4.5者;不同级别TCT异常,均可发现有DNA指数异常细胞,TCT病变级别越高,DNA倍体异常细胞和异倍体细胞峰出现频率越大;不同程度的DNA异常其高危型HPV感染率差异有统计学意义(x2=62.648,P=0.000).结论 DNA定量分析联合TCT作为宫颈癌筛查方法有可行性,可以减少漏诊和误诊,指导临床进行宫颈活检,对高危型HPV感染起提示作用.
目的 比較DNA定量分析與薄層液基細胞學(TCT)檢查在宮頸癌中的應用價值,以提高細胞學診斷的準確性.方法 對7 470例婦女行宮頸薄層液基細胞學(TCT)及DNA定量分析,結果異常者用二代基因雜交捕穫法(HC2)檢測高危型人乳頭狀瘤病毒(HPV),TCT在ASC及以上病變為暘性,DNA指數≥2.5為暘性.結果 7470例患者,用DNA定量分析法檢測暘性率為13.0%,TCT檢查暘性率為13.7%,兩種檢查方法差異無統計學意義(x2 =1.813,P=0.178);≥3箇細胞2.5≤DNA指數<4.5者及DNA指數≥4.5者的TCT暘性率明顯高于<3箇細胞2.5≤DNA指數<4.5者;不同級彆TCT異常,均可髮現有DNA指數異常細胞,TCT病變級彆越高,DNA倍體異常細胞和異倍體細胞峰齣現頻率越大;不同程度的DNA異常其高危型HPV感染率差異有統計學意義(x2=62.648,P=0.000).結論 DNA定量分析聯閤TCT作為宮頸癌篩查方法有可行性,可以減少漏診和誤診,指導臨床進行宮頸活檢,對高危型HPV感染起提示作用.
목적 비교DNA정량분석여박층액기세포학(TCT)검사재궁경암중적응용개치,이제고세포학진단적준학성.방법 대7 470례부녀행궁경박층액기세포학(TCT)급DNA정량분석,결과이상자용이대기인잡교포획법(HC2)검측고위형인유두상류병독(HPV),TCT재ASC급이상병변위양성,DNA지수≥2.5위양성.결과 7470례환자,용DNA정량분석법검측양성솔위13.0%,TCT검사양성솔위13.7%,량충검사방법차이무통계학의의(x2 =1.813,P=0.178);≥3개세포2.5≤DNA지수<4.5자급DNA지수≥4.5자적TCT양성솔명현고우<3개세포2.5≤DNA지수<4.5자;불동급별TCT이상,균가발현유DNA지수이상세포,TCT병변급별월고,DNA배체이상세포화이배체세포봉출현빈솔월대;불동정도적DNA이상기고위형HPV감염솔차이유통계학의의(x2=62.648,P=0.000).결론 DNA정량분석연합TCT작위궁경암사사방법유가행성,가이감소루진화오진,지도림상진행궁경활검,대고위형HPV감염기제시작용.
Objective To compare the cytology diagnostic accuracy of DNA quantitative cytology and thinprep cytology test(TCT) in cervical cancer screening for exploring effective method in cervical cancer screening.Methods TCT and DNA quantitative cytology were carried out in 7 470 women.Women with positive results additionally underwent high risk human papillomavirus (HPV) detection.Positive cytologic diagnosis included atypical squamous cells(ASC) or above in TCT and DNA index 2.5 or above in DNA quantitative cytology.Results The positive rate was 13.0% in method of DNA quantitative cytology and 13.7% in method of TCT in 7 470 cases.Positive rate of the two methods had no significant difference in cervical cancer screening(x2 =1.813,P =0.178).There was significant difference in positive rate of TCT between cases with DNA index≥2.5,<4.5,heteroploid cells more than 3 or DNA index≥4.5 and cases with DNA index≥2.5,<4.5,heteroploid cells less than 3.Every grade of TCT abnormality had abnormal DNA index.Abnormality of DNA index had an increasing trend with the severity of TCT.Infection rate of high risk HPVs had significant difference in different grades of DNA index (x2 =62.648,P =0.000).Conclusion Combination of DNA quantitative cytology and TCT is an effective method in cervical cancer screening,which can reduce misdiagnosis,guide cervical biopsy and suggest infection of high risk of HPVs.