健康之路
健康之路
건강지로
HEALTH
2013年
7期
32-32,33
,共2页
刘晓艳%谢粟梅%李青青%李秀凤
劉曉豔%謝粟梅%李青青%李秀鳳
류효염%사속매%리청청%리수봉
琥珀酸索利那新%脊髓损伤%逼尿肌过度活动
琥珀痠索利那新%脊髓損傷%逼尿肌過度活動
호박산색리나신%척수손상%핍뇨기과도활동
Solifenacin succinate%Spinal cord injury (SCI)%Detrusor overactivity
目的：评估琥珀酸索利那新治疗脊髓损伤后逼尿肌过度活动的疗效。方法：将36例经尿流动力学检查证实存在逼尿肌过度活动的脊髓损伤患者随机分为2组：对照组18例，给予一般性治疗，如饮水计划、间歇性导尿等；实验组18例，在一般性治疗基础上给予口服琥珀酸索利那新5mg/次，1次/d。两组疗程均为6周。两组患者在治疗前1周及治疗6周后行尿流动力学检查，观察储尿期最大逼尿肌压力、膀胱安全容量变化情况，同时行超声检查，了解治疗前后残余尿量情况，对治疗效果进行评价。结果：两组患者治疗后各观察指标均明显改善（P＜0．001），与对照组相比，实验组患者的储尿期最大逼尿肌压力降低、膀胱安全容量增加更为明显，差异具统计学意义（P＜0．05），对照组残余尿量减少而实验组残余尿量明显增加（P＜0．01）。结论：琥珀酸索利那新治疗脊髓损伤后逼尿肌过度活动，可降低储尿期最大逼尿肌压力及提高膀胱安全容量，减少尿失禁，有较好的疗效。
目的：評估琥珀痠索利那新治療脊髓損傷後逼尿肌過度活動的療效。方法：將36例經尿流動力學檢查證實存在逼尿肌過度活動的脊髓損傷患者隨機分為2組：對照組18例，給予一般性治療，如飲水計劃、間歇性導尿等；實驗組18例，在一般性治療基礎上給予口服琥珀痠索利那新5mg/次，1次/d。兩組療程均為6週。兩組患者在治療前1週及治療6週後行尿流動力學檢查，觀察儲尿期最大逼尿肌壓力、膀胱安全容量變化情況，同時行超聲檢查，瞭解治療前後殘餘尿量情況，對治療效果進行評價。結果：兩組患者治療後各觀察指標均明顯改善（P＜0．001），與對照組相比，實驗組患者的儲尿期最大逼尿肌壓力降低、膀胱安全容量增加更為明顯，差異具統計學意義（P＜0．05），對照組殘餘尿量減少而實驗組殘餘尿量明顯增加（P＜0．01）。結論：琥珀痠索利那新治療脊髓損傷後逼尿肌過度活動，可降低儲尿期最大逼尿肌壓力及提高膀胱安全容量，減少尿失禁，有較好的療效。
목적：평고호박산색리나신치료척수손상후핍뇨기과도활동적료효。방법：장36례경뇨류동역학검사증실존재핍뇨기과도활동적척수손상환자수궤분위2조：대조조18례，급여일반성치료，여음수계화、간헐성도뇨등；실험조18례，재일반성치료기출상급여구복호박산색리나신5mg/차，1차/d。량조료정균위6주。량조환자재치료전1주급치료6주후행뇨류동역학검사，관찰저뇨기최대핍뇨기압력、방광안전용량변화정황，동시행초성검사，료해치료전후잔여뇨량정황，대치료효과진행평개。결과：량조환자치료후각관찰지표균명현개선（P＜0．001），여대조조상비，실험조환자적저뇨기최대핍뇨기압력강저、방광안전용량증가경위명현，차이구통계학의의（P＜0．05），대조조잔여뇨량감소이실험조잔여뇨량명현증가（P＜0．01）。결론：호박산색리나신치료척수손상후핍뇨기과도활동，가강저저뇨기최대핍뇨기압력급제고방광안전용량，감소뇨실금，유교호적료효。
Objective :To evaluate the efficacy and safety of solifenacin succinate therapy in patients with Neurogenic detrusor overactivity (NDO) after spinal cord injury .Methods :A total of 36 patients with NDO were enrolled in the trial and were randomly divided into two groups ,experimen-tal group(n=18) and control group(n=18) .Patients in control group were only received general treatment ,such as drinking water follow scheme and intermittent catheterization .Solifenacin succinate was taken 5mg once a day for 6 weeks by patients in experimental group .The courses of treat-ment were lasted for six weeks in both groups .Urination diary was recorded by all patients in both groups one week before and after treatment .The efficacy of solifenacin succinate was assessed by comparing the changes of maximum detrusor pressure ,bladder security capacity and residual urine volume in two groups .Result:After treatment ,the maximum detrusor pressure in urine storage stage ,bladder security capacity and residual urine volume were significantly improved in both groups (P<0 .001) .Compared with control group ,the maximum detrusor pressure in urine storage stage decreased and bladder security capacity increased significantly (P< 0 .05) in patients of experimental group .The residual urine volume of patients were decreased in control group while increased in experimental group (P<0 .01) .Conclusion:Solifenacin succinate therapy can reduce the maximum detrusor pressure in urine storage ,improve bladder security capacity and reduce incontinence in patients with Neurogenic detrusor overactivity after spinal cord injury .
