风湿病与关节炎
風濕病與關節炎
풍습병여관절염
Rheumatism and Arthritis
2013年
7期
32-34
,共3页
庞学丰%王乾%吴燕红%唐丽萍%黄婵娟%彭忠异%刘欢%龙朝阳%潘燕%李玉玲
龐學豐%王乾%吳燕紅%唐麗萍%黃嬋娟%彭忠異%劉歡%龍朝暘%潘燕%李玉玲
방학봉%왕건%오연홍%당려평%황선연%팽충이%류환%룡조양%반연%리옥령
关节炎,胶原诱导性%寒痹康汤%核转录因子-κB
關節炎,膠原誘導性%寒痺康湯%覈轉錄因子-κB
관절염,효원유도성%한비강탕%핵전록인자-κB
arthritis,collagen-induced%hanbikang decoction%NF-κB
目的：观察寒痹康汤对胶原诱导性关节炎大鼠滑膜细胞核转录因子-κB表达的影响，初步揭示寒痹康汤治疗类风湿关节炎的机理。方法：采用牛Ⅱ型胶原蛋白和弗氏不完全佐剂诱导关节炎大鼠模型，以甲氨蝶呤为对照组，观察寒痹康汤对各组大鼠滑膜细胞核转录因子-κB表达的影响。结果：寒痹康汤能降低胶原诱导性关节炎大鼠滑膜细胞核转录因子-κB的表达，作用与甲氨蝶呤相当。结论：寒痹康汤影响胶原诱导性关节炎大鼠滑膜细胞核转录因子-κB的表达，是其治疗类风湿关节炎的机理之一。
目的：觀察寒痺康湯對膠原誘導性關節炎大鼠滑膜細胞覈轉錄因子-κB錶達的影響，初步揭示寒痺康湯治療類風濕關節炎的機理。方法：採用牛Ⅱ型膠原蛋白和弗氏不完全佐劑誘導關節炎大鼠模型，以甲氨蝶呤為對照組，觀察寒痺康湯對各組大鼠滑膜細胞覈轉錄因子-κB錶達的影響。結果：寒痺康湯能降低膠原誘導性關節炎大鼠滑膜細胞覈轉錄因子-κB的錶達，作用與甲氨蝶呤相噹。結論：寒痺康湯影響膠原誘導性關節炎大鼠滑膜細胞覈轉錄因子-κB的錶達，是其治療類風濕關節炎的機理之一。
목적：관찰한비강탕대효원유도성관절염대서활막세포핵전록인자-κB표체적영향，초보게시한비강탕치료류풍습관절염적궤리。방법：채용우Ⅱ형효원단백화불씨불완전좌제유도관절염대서모형，이갑안접령위대조조，관찰한비강탕대각조대서활막세포핵전록인자-κB표체적영향。결과：한비강탕능강저효원유도성관절염대서활막세포핵전록인자-κB적표체，작용여갑안접령상당。결론：한비강탕영향효원유도성관절염대서활막세포핵전록인자-κB적표체，시기치료류풍습관절염적궤리지일。
Objective:To observe the effect of hanbikang decoction on the expression of NF-κB in synovial cells of collagen-induced rats with rheumatoid arthritis to probe the mechanism of it in the treatment of rheumatoid arthritis.Methods:Bovine collagen type II and freund's incomplete adjuvant were used to induce rat model with arthritis to observe the expression of NF-κB in synovial cells of collagen-induced rats with rheumatoid arthritis with methotrexate as the control group.Results:Hanbikang decoction could reduce the expression of NF-κB in synovial cells of collagen-induced rats with rheumatoid arthritis,with almost the same function as methotrexate.Conclusion:Hanbikang decoction could influence the expression of NF-κB in synovial cells of collagen-induced rats with rheumatoid arthritis,being one of the mechanisms in the treatment of rheumatoid arthritis.
