风湿病与关节炎
風濕病與關節炎
풍습병여관절염
Rheumatism and Arthritis
2013年
7期
22-25
,共4页
吴茂春%薛原%林星%刘城亮
吳茂春%薛原%林星%劉城亮
오무춘%설원%림성%류성량
关节炎,类风湿%瘦素%瘦素受体
關節炎,類風濕%瘦素%瘦素受體
관절염,류풍습%수소%수소수체
arthritis,rheumatoid%leptin%leptin receptor
目的：探讨瘦素及可溶性瘦素受体在类风湿关节炎患者血清中的变化规律。方法：选择女性类风湿关节炎患者88例，未治疗组40例，治疗后组48例；健康女性48例为正常对照组，用酶联免疫吸附方法检测瘦素、可溶性瘦素受体及抗环瓜氨酸肽抗体；用免疫比浊法测定C-反应蛋白。结果：与正常对照组比较，未治疗组类风湿关节炎患者血清瘦素水平显著增高（P<0.01），血清可溶性瘦素受体水平无显著变化（P＝0.05）。治疗后组与未治疗组比较，血清瘦素水平显著下降（P<0.01），可溶性瘦素受体水平显著提高（P<0.01）。治疗后组与正常对照组比较，血清瘦素水平显著下降（P<0.05），血清可溶性瘦素受体水平显著提高（P<0.01）。治疗前后血清瘦素与可溶性瘦素受体水平呈负相关（r值分别为-0.35，-0.319；P<0.05），未治疗组血清瘦素、可溶性瘦素受体与C-反应蛋白无相关（P>0.05），治疗后血清瘦素与C-反应蛋白正相关（r=0.358；P<0.05），治疗后瘦素水平与抗CCP抗体滴度呈正相关（r=0.343；P<0.05）。结论：类风湿关节炎患者治疗前后血清瘦素与可溶性瘦素受体水平均存在显著异常。通过对治疗前后瘦素与可溶性瘦素受体血清水平的分析，进一步认识类风湿关节炎的发病机制。
目的：探討瘦素及可溶性瘦素受體在類風濕關節炎患者血清中的變化規律。方法：選擇女性類風濕關節炎患者88例，未治療組40例，治療後組48例；健康女性48例為正常對照組，用酶聯免疫吸附方法檢測瘦素、可溶性瘦素受體及抗環瓜氨痠肽抗體；用免疫比濁法測定C-反應蛋白。結果：與正常對照組比較，未治療組類風濕關節炎患者血清瘦素水平顯著增高（P<0.01），血清可溶性瘦素受體水平無顯著變化（P＝0.05）。治療後組與未治療組比較，血清瘦素水平顯著下降（P<0.01），可溶性瘦素受體水平顯著提高（P<0.01）。治療後組與正常對照組比較，血清瘦素水平顯著下降（P<0.05），血清可溶性瘦素受體水平顯著提高（P<0.01）。治療前後血清瘦素與可溶性瘦素受體水平呈負相關（r值分彆為-0.35，-0.319；P<0.05），未治療組血清瘦素、可溶性瘦素受體與C-反應蛋白無相關（P>0.05），治療後血清瘦素與C-反應蛋白正相關（r=0.358；P<0.05），治療後瘦素水平與抗CCP抗體滴度呈正相關（r=0.343；P<0.05）。結論：類風濕關節炎患者治療前後血清瘦素與可溶性瘦素受體水平均存在顯著異常。通過對治療前後瘦素與可溶性瘦素受體血清水平的分析，進一步認識類風濕關節炎的髮病機製。
목적：탐토수소급가용성수소수체재류풍습관절염환자혈청중적변화규률。방법：선택녀성류풍습관절염환자88례，미치료조40례，치료후조48례；건강녀성48례위정상대조조，용매련면역흡부방법검측수소、가용성수소수체급항배과안산태항체；용면역비탁법측정C-반응단백。결과：여정상대조조비교，미치료조류풍습관절염환자혈청수소수평현저증고（P<0.01），혈청가용성수소수체수평무현저변화（P＝0.05）。치료후조여미치료조비교，혈청수소수평현저하강（P<0.01），가용성수소수체수평현저제고（P<0.01）。치료후조여정상대조조비교，혈청수소수평현저하강（P<0.05），혈청가용성수소수체수평현저제고（P<0.01）。치료전후혈청수소여가용성수소수체수평정부상관（r치분별위-0.35，-0.319；P<0.05），미치료조혈청수소、가용성수소수체여C-반응단백무상관（P>0.05），치료후혈청수소여C-반응단백정상관（r=0.358；P<0.05），치료후수소수평여항CCP항체적도정정상관（r=0.343；P<0.05）。결론：류풍습관절염환자치료전후혈청수소여가용성수소수체수평균존재현저이상。통과대치료전후수소여가용성수소수체혈청수평적분석，진일보인식류풍습관절염적발병궤제。
Objective:To explore the changes of leptin and soluble leptin receptor (sOB-R)in serum of patients with rheumatoid arthritis(RA).Methods:Three groups of female were enrolled:40 untreated and 48 treated with RA,and 48 health controls who have no significantly different body mass index(BMI)from those above.The leptin and soluble leptin receptor were measured by enzyme-linked immunosorbent assay.C-reactive protein was measured by immunoturbidimetry and the anti cyclic citrullinated peptide(CCP)antibody was measured by enzyme-linked immunoturbidimetry.Results:Compared with the health controls,the level of leptin in serum increased significantly(P<0.01)and the level of soluble leptin receptor in it had no significant change (P=0.05)in the untreated group.And in the treated group,the level of leptin decreased significantly(P<0.01) and the level of soluble leptin receptor increased significantly(P<0.01)compared with the health controls or the untreated group.Compared with the health controls,the level of leptin in serum significantly decreased(P<0.05) and the level of soluble leptin receptor increased obviously(P<0.01).There was a negative correlation between the level of leptin and that of the soluble leptin receptor before and after the treatment(r=-0.35,-0.319;P<0.05).In untreated group the levels of leptin and soluble leptin receptor had no correlation with C-reactive protein(P > 0.05). And in the treated group,the leptin had positive corelation with C-reactive protein(r=0.358;P<0.05)and so did the level of leptin with the anti cyclic citrullinated peptide(CCP)antibody(r=0.358,0.343;P<0.05).Conclusion:The levels of leptin and soluble leptin receptor were obviously different in patients with RA before and after the treatment.The pathogenesis of RA could be further known by analysis of the levels of leptin and soluble leptin receptor before and after treatment.
