CAJ | 학술논문

　　目的：探讨老年性脑梗死与高同型半胱氨酸血症的关系。方法：回顾性分析我院收治的78例老年性脑梗死患者（观察组）与50例同龄健康体检者（对照组）的临床资料，两组均测定同型半胱氨酸（Hcy）、叶酸（FA）、维生素B12、总胆固醇（TC）、三酰甘油（TG）、高密度脂蛋白（HDL-C）、低密度脂蛋白（LDL-C），并对检测结果进行比较分析。结果：观察组Hcy水平明显高于对照组（P<0.01），而叶酸与维生素B12水平均低于对照组（P<0.01）；两组TC、TG、HDL-C、LDL-C水平均无显著性差异（P>0.05）。结论：高同型半胱氨酸血症与老年性脑梗死密切相关，是老年脑梗死的重要危险因素，叶酸和维生素B12缺乏是导致高同型半胱氨酸血症的重要原因。
　　목적：탐토노년성뇌경사여고동형반광안산혈증적관계。방법：회고성분석아원수치적78례노년성뇌경사환자（관찰조）여50례동령건강체검자（대조조）적림상자료，량조균측정동형반광안산（Hcy）、협산（FA）、유생소B12、총담고순（TC）、삼선감유（TG）、고밀도지단백（HDL-C）、저밀도지단백（LDL-C），병대검측결과진행비교분석。결과：관찰조Hcy수평명현고우대조조（P<0.01），이협산여유생소B12수평균저우대조조（P<0.01）；량조TC、TG、HDL-C、LDL-C수평균무현저성차이（P>0.05）。결론：고동형반광안산혈증여노년성뇌경사밀절상관，시노년뇌경사적중요위험인소，협산화유생소B12결핍시도치고동형반광안산혈증적중요원인。
Objective:To investigate the relationship between senile cerebral infarction and hyperhomocysteinemia. Methods:The clinical data were retrospectively analyzed in 78 cases of patients with senile cerebral infarction (observation group) and 50 cases of healthy testers (control group) in our hospital. Homocysteine (Hcy), folic acid (FA), vitamin B12, total cholesterol (TC), triacylglycerol (TG), high-density lipoprotein (HDL-C) and low-density lipoprotein (LDL-C) of two groups were tested and comparatively analyzed. Results:Hcy level of observation group was significantly higher than that of control group (P<0.01), and levels of folic acid and vitamin B12 in observation group were lower than those in control group (P<0.01);there were no significant differences of TC, TG, HDL-C, LDL-C levels between two groups (P>0.05). Conclusion:Hyperhomocysteinemia, which is an important risky factor for senile cerebral infarction, is closely related with senile cerebral infarction, and deficiency of folic acid and vita-min B12 is an important cause of hyperhomocysteinemia.