CAJ | 학술논문

目的探讨可降解镁合金吻合器应用于动物胃肠道吻合手术的可行性及安全性.方法将16只比格犬分为实验组及对照组,每组8只.实验组以镁合金吻合器进行吻合手术；对照组以钛合金吻合器进行吻合手术；每只比格犬均进行胃空肠及结肠两处吻合,比较两组间的吻合时间、手术后并发症、体质量变化、吻合口爆破压和血清镁离子浓度以及谷丙转氨酶、谷草转氨酶、尿素氮、肌酐浓度,观察镁合金吻合钉的降解情况,对比观察吻合口愈合及心、肝、肾、脑、脾的组织病理学标本.结果两组间吻合时间、手术后并发症、体质量变化、吻合口爆破压、镁离子浓度、肝肾功能等差异均无统计学意义；组织病理学检查见吻合口愈合良好,无炎性细胞浸润；上述脏器的组织病理学检查未见明显差异,镁合金在吻合术后90 d内可完全降解.结论镁合金吻合器进行胃肠道吻合手术安全可行,其降解过程对吻合口局部及其他重要脏器无不良影响,有望应用于人体胃肠道吻合手术中.
목적 탐토가강해미합금문합기응용우동물위장도문합수술적가행성급안전성.방법 장16지비격견분위실험조급대조조,매조8지.실험조이미합금문합기진행문합수술；대조조이태합금문합기진행문합수술；매지비격견균진행위공장급결장량처문합,비교량조간적문합시간、수술후병발증、체질량변화、문합구폭파압화혈청미리자농도이급곡병전안매、곡초전안매、뇨소담、기항농도,관찰미합금문합정적강해정황,대비관찰문합구유합급심、간、신、뇌、비적조직병이학표본.결과 량조간문합시간、수술후병발증、체질량변화、문합구폭파압、미리자농도、간신공능등차이균무통계학의의；조직병이학검사견문합구유합량호,무염성세포침윤；상술장기적조직병이학검사미견명현차이,미합금재문합술후90 d내가완전강해.결론 미합금문합기진행위장도문합수술안전가행,기강해과정대문합구국부급기타중요장기무불량영향,유망응용우인체위장도문합수술중.
Objective To explore the safety and feasibility of biodegradable magnesium alloy stapler based on the result of animal experimental study for gastrointestinal anastomosis.Methods Sixteen beagle dogs were equally and randomly divided into experimental (magnesium alloy) group and control (titanium alloy) group.A gastrojejunal and a colonic anastomosis were performed in each beagle dog.The anastomosis time,postoperative complications,body weight,blasting pressure of anastomosis and serum glutamic pyruvic transaminase,glutamic oxaloacetic transaminase,creatinine,blood urea nitrogen,and serum magnesium were compared between the two groups.The healing of anastomosis and degradation of magnesium alloy were observed.The histopathological feasures of heart,liver,spleen and kidney were examined in the two groups.Results There were no significant differences in anastomosis time,body weight,postoperative complications,anastomotic bursting pressure between the two groups.The anastomosis was healed well,and no dramatic inflammatory cell infiltration was observed.Magnesium alloy could be degraded completely in the animal body within 90 days.There were no significant differences in serum glutamic pyruvic transaminase,glutamic oxaloacetic transaminase,creatinine,blood urea nitrogen and serum magnesium between the two groups.Histopathological examination showed that the degradation of magnesium alloy did not harm the important organs(liver,kidney,heart,brain and spleen).Conclusions Magnesium alloy stapler is safe and feasible for gastrointestinal anastomosis in beagle dogs.The degradation of magnesium alloy does not harm the healing of anastomosis and other important organs.Magnesium alloy stapler may be a candidate of biodegradable and safe material of stapler for gastrointestinal anastomosis in human.