CAJ | 학술논문

目的：探讨抑癌基因PTEN表达与非小细胞肺癌（ non-small-cell lung carcinoma ， NSCLC）发生和发展的关系。方法应用免疫组织化学法检测45例非小细胞肺癌组织和相应癌旁组织中PTEN的表达。结果 PTEN在非小细胞癌组织和相应癌旁组织中阳性表达率分别为31.1％和66.7％，差异有统计学意义（ P＝0.001）；PTEN表达与非小细胞肺癌分化相关（ P＝0.000），与患者年龄、性别，肿瘤分型、分期和淋巴结转移无关。结论 PTEN与非小细胞肺癌发生和发展相关。
목적：탐토억암기인PTEN표체여비소세포폐암（ non-small-cell lung carcinoma ， NSCLC）발생화발전적관계。방법응용면역조직화학법검측45례비소세포폐암조직화상응암방조직중PTEN적표체。결과 PTEN재비소세포암조직화상응암방조직중양성표체솔분별위31.1％화66.7％，차이유통계학의의（ P＝0.001）；PTEN표체여비소세포폐암분화상관（ P＝0.000），여환자년령、성별，종류분형、분기화림파결전이무관。결론 PTEN여비소세포폐암발생화발전상관。
Objective To investigate whether the expression of phosphatase and tensin homolog deleted on chromosome ten ( PTEN) is involved in the initiation and progression of non-small-cell lung carcinoma (NSCLC).Methods The expression of PTEN was detected in 45 paired NSCLC tumor and adjacent normal tissues by immunohistochemistry .Results The positive ex-pression rates of PTEN in NSCLC tumor and normal tissues were 31 .1% and 66 .7% respec-tively, the difference was statistically significant ( P =0.001 ) .PTEN expressions correlated with the differentiation of the tumor ( P=0.000 ) .Conclusion Lack of PTEN expression may be involved in the initiation and progression of NSCLC .