CAJ | 학술논문

目的：研究慢性阻塞性肺疾病（ chronic obstructive pulmonary disease ， COPD）患者中瘦素（ lep-tin）、白介素-6（ IL-6）的表达来分析leptin、IL-6在此种疾病中的作用及意义，研究leptin与IL-6的相关性。方法 COPD患者分为急性加重期（ acute exacerbatiors of COPD ， AECOPD）组、稳定期组和正常对照组。采集各组病例的血清及痰液，放免法测定leptin及IL-6的水平，分析两者在各组之间的差异及其相关性。结果 AECOPD患者血清leptin和IL-6明显高于正常对照组及稳定期患者，稳定期患者血清二者水平较正常对照组略有升高，差异无统计学意义（ P＞0.05）。 AECOPD患者痰液leptin和IL-6较稳定期患者及正常对照组显著增高，稳定期患者痰液中二者的表达较正常组略有升高，差异无统计学意义（P＞0.05）。同时AECOPD患者血清白蛋白（ALB）较稳定期患者及正常对照组明显减低，AECOPD组患者白细胞（ WBC）较稳定期患者及正常对照组明显升高，AECOPD组患者肺功值较稳定期患者及正常对照组明显下降。稳定期患者ALB和肺功较正常对照组有所降低，WBC水平略有升高，两组间肺功差异有统计学意义（ P＜0.05），而ALB及WBC差异无统计学意义（ P＞0.05）。结论 Leptin与IL-6在COPD的发生、发展过程中起着一定的作用，与COPD的病情严重程度有关。
목적：연구만성조새성폐질병（ chronic obstructive pulmonary disease ， COPD）환자중수소（ lep-tin）、백개소-6（ IL-6）적표체래분석leptin、IL-6재차충질병중적작용급의의，연구leptin여IL-6적상관성。방법 COPD환자분위급성가중기（ acute exacerbatiors of COPD ， AECOPD）조、은정기조화정상대조조。채집각조병례적혈청급담액，방면법측정leptin급IL-6적수평，분석량자재각조지간적차이급기상관성。결과 AECOPD환자혈청leptin화IL-6명현고우정상대조조급은정기환자，은정기환자혈청이자수평교정상대조조략유승고，차이무통계학의의（ P＞0.05）。 AECOPD환자담액leptin화IL-6교은정기환자급정상대조조현저증고，은정기환자담액중이자적표체교정상조략유승고，차이무통계학의의（P＞0.05）。동시AECOPD환자혈청백단백（ALB）교은정기환자급정상대조조명현감저，AECOPD조환자백세포（ WBC）교은정기환자급정상대조조명현승고，AECOPD조환자폐공치교은정기환자급정상대조조명현하강。은정기환자ALB화폐공교정상대조조유소강저，WBC수평략유승고，량조간폐공차이유통계학의의（ P＜0.05），이ALB급WBC차이무통계학의의（ P＞0.05）。결론 Leptin여IL-6재COPD적발생、발전과정중기착일정적작용，여COPD적병정엄중정도유관。
Objective To study the expression of leptin and interleukin-6 ( IL-6 ) in patients with chronic obstructive pulmonary disease ( COPD) and to analyze the role and significance . Methods COPD patients were divided into 2 groups: acute exacerbations of COPD ( AECO-PD) and stable COPD .Controls were healthy subjects .Leptin and IL-6 were compared in ser-um and sputum samples .Results In AECOPD patients , leptin and IL-6 in both serum and sputum were significantly higher than those in stable COPD patients and controls , stable COPD patients with serum and sputum levels slightly higher than controls , there was no statistically significant difference .AECOPD patients with serum albumin ( ALB ) was significantly lower than stable COPD patients and controls , white blood cell ( WBC ) was significantly increased than stable COPD patients and controls .AECOPD patients with pulmonary function values de-creased significantly than stable COPD patients and controls .ALB and lung function values in stable COPD patients decreased compared with controls , WBC levels increased slightly , there was significant difference between the two groups in lung function ( P<0.05 ) , while ALB and WBC had no significant difference ( P>0.05 ) .Conclusion Leptin and IL-6 play important roles in the occurrence and development of COPD .It is associated with the disease severity of COPD.