CAJ | 학술논문

目的：探讨脂代谢紊乱在2型糖尿病中的表现和作用。方法将2型糖尿病患者分为伴有高胰岛素血症（ hyperinsulinemia ， HINSE）和不伴有HINSE两组；用荧光偏振技术测量红细胞膜的流动性；用荧光分光光度计测量血浆的自体荧光发射光谱。结果伴HINSE组较不伴HINSE组，红细胞膜的微粘度增大，流动性降低；糖尿病患者在445 nm的荧光峰明显增强，且伴HINSE组较不伴HINSE组增强明显。结论2型糖尿病患者高胰岛素血症导致脂质代谢紊乱，红细胞变形性下降，膜流动性和通透性改变。脂质过氧化反应和血脂异常导致血浆自体荧光光谱改变。
목적：탐토지대사문란재2형당뇨병중적표현화작용。방법장2형당뇨병환자분위반유고이도소혈증（ hyperinsulinemia ， HINSE）화불반유HINSE량조；용형광편진기술측량홍세포막적류동성；용형광분광광도계측량혈장적자체형광발사광보。결과반HINSE조교불반HINSE조，홍세포막적미점도증대，류동성강저；당뇨병환자재445 nm적형광봉명현증강，차반HINSE조교불반HINSE조증강명현。결론2형당뇨병환자고이도소혈증도치지질대사문란，홍세포변형성하강，막류동성화통투성개변。지질과양화반응화혈지이상도치혈장자체형광광보개변。
Objective To explore the performance and role of lipid disorders in type 2 diabetes mellitus ( DM) .Methods Patients with type 2 DM were divided into 2 groups:with hyperin-sulinemia ( HINSE) and without HINSE .The membrane fluidity of red blood cell was meas-ured by fluorescence polarization technology .The fluorescence emission spectrums were meas-ured and analyzed by spectrophotofluorometer .Results Compared with type 2 DM without HINSE, the micro viscosity of red cell membrane was increased , liquidity was reduced; the fluorescence peak in 445 nm increased obviously , which of type 2 DM with HINSE increased more significantly than those of without HINSE .Conclusion Type 2 DM with HINSE leads to lipid disorders , decrease of red cell deformability , membrane fluidity and permeability .Lipid peroxidatic reaction and blood fat abnormality lead to plasma auto-fluorescence changing .