河北北方学院学报(自然科学版)
河北北方學院學報(自然科學版)
하북북방학원학보(자연과학판)
JOURNAL OF HEBEI NORTH UNIVERSITY(NATURAL SCIENCE EDITION)
2013年
5期
62-64
,共3页
宗晓春%彭一%张贵山%戚翔
宗曉春%彭一%張貴山%慼翔
종효춘%팽일%장귀산%척상
地特胰岛素%甘精胰岛素%中效胰岛素%格列美脲%2 型糖尿病
地特胰島素%甘精胰島素%中效胰島素%格列美脲%2 型糖尿病
지특이도소%감정이도소%중효이도소%격렬미뇨%2 형당뇨병
insulin detemir%insulin glargine%neutral protamine hagedorn insulin%glimepiride%type 2 diabetes
目的:观察应用地特胰岛素、甘精胰岛素与中效胰岛素分别联合格列美脲治疗口服降糖药联合治疗控制不佳的2型糖尿病的疗效和安全性。方法选取93例2型糖尿病或口服降糖药联合治疗控制不佳的2型糖尿病患者,按随机分配的原则,分别应用上述三种基础胰岛素联合格列美脲降糖治疗,比较胰岛素使用剂量,降糖效果,体重变化情况,低血糖发生次数等。结果三组降糖效果比较差异无统计学意义(P >0.05);Det 组(地特胰岛素组)体重增加明显低于 Gla 组(甘精胰岛素组)和 NPH 组(中效胰岛素组)(P <0.05);NPH 组低血糖发生率较前2组明显升高,Det 组和 Gla 组低血糖发生率相近。结论2型糖尿病患者应用中长效胰岛素联合格列美脲降糖治疗,长效胰岛素类似物在安全性及体重增加方面更有优势。
目的:觀察應用地特胰島素、甘精胰島素與中效胰島素分彆聯閤格列美脲治療口服降糖藥聯閤治療控製不佳的2型糖尿病的療效和安全性。方法選取93例2型糖尿病或口服降糖藥聯閤治療控製不佳的2型糖尿病患者,按隨機分配的原則,分彆應用上述三種基礎胰島素聯閤格列美脲降糖治療,比較胰島素使用劑量,降糖效果,體重變化情況,低血糖髮生次數等。結果三組降糖效果比較差異無統計學意義(P >0.05);Det 組(地特胰島素組)體重增加明顯低于 Gla 組(甘精胰島素組)和 NPH 組(中效胰島素組)(P <0.05);NPH 組低血糖髮生率較前2組明顯升高,Det 組和 Gla 組低血糖髮生率相近。結論2型糖尿病患者應用中長效胰島素聯閤格列美脲降糖治療,長效胰島素類似物在安全性及體重增加方麵更有優勢。
목적:관찰응용지특이도소、감정이도소여중효이도소분별연합격렬미뇨치료구복강당약연합치료공제불가적2형당뇨병적료효화안전성。방법선취93례2형당뇨병혹구복강당약연합치료공제불가적2형당뇨병환자,안수궤분배적원칙,분별응용상술삼충기출이도소연합격렬미뇨강당치료,비교이도소사용제량,강당효과,체중변화정황,저혈당발생차수등。결과삼조강당효과비교차이무통계학의의(P >0.05);Det 조(지특이도소조)체중증가명현저우 Gla 조(감정이도소조)화 NPH 조(중효이도소조)(P <0.05);NPH 조저혈당발생솔교전2조명현승고,Det 조화 Gla 조저혈당발생솔상근。결론2형당뇨병환자응용중장효이도소연합격렬미뇨강당치료,장효이도소유사물재안전성급체중증가방면경유우세。
Objective To compare the efficacy and safety of insulin detemir,insulin glargine and novo-lin N combined with glimepiride for treating patients with type 2 diabetes.Methods Ninety cases with type 2 diabetes were randomly divided into three groups,group A (treated with insulin detemir combined with glimepiride),group B (treated with insulin glargine combined with glimepiride)and group C (trea-ted with novolin N combined with glimepiride).Efficacy parameters pre-post treatment including fasting plasma glucose (FPG)and 2-hour postprandial plasma glucose (2h-PPG),hypoglycemia,time of glyce-mic control and dosage of insulin were measured and recorded.Results After treatment,all FPG、2h-PPG and Glycosylated hemoglobin (HbA1c) were significantly decreased than that before treatment (P <0.05).But there were no significant differences in three groups in those indexes (P >0.05).The inci-dence of hypoglycemia was less in group A compared with that of group C (P <0.05).The weight gain was less in group A than that of groups B and C (P < 0.05).Conclusion Compared with novolin N group,insulin detemir group and insulin glargine group could have similar efficacy but lower in the risk of hypoglycemia and less in weight gain.