CAJ | 학술논문

目的：探讨骨肉瘤组织CD147、MMP-2蛋白的表达及意义。方法：应用免疫组织化学染色SP法检测37例骨肉瘤及10例骨软骨瘤CD147和MMP-2的表达。结果：骨肉瘤中CD147、MMP-2的阳性表达率均明显高于骨软骨瘤；骨肉瘤中CD147、MMP-2的阳性表达与Enneking分期和肺转移有关，且二者的表达呈正相关(P＜0.01)。结论：CD147和MMP-2在骨肉瘤的浸润和转移方面起重要作用，联合检测CD147和MMP-2有望成为判断骨肉瘤预后的新指标。
목적：탐토골육류조직CD147、MMP-2단백적표체급의의。방법：응용면역조직화학염색SP법검측37례골육류급10례골연골류CD147화MMP-2적표체。결과：골육류중CD147、MMP-2적양성표체솔균명현고우골연골류；골육류중CD147、MMP-2적양성표체여Enneking분기화폐전이유관，차이자적표체정정상관(P＜0.01)。결론：CD147화MMP-2재골육류적침윤화전이방면기중요작용，연합검측CD147화MMP-2유망성위판단골육류예후적신지표。
Objective:To investigate the expression and significance of CD147 and MMP-2 in osteosarcoma. Methods:SP immunohistochemical staining was used to detect the expression of CD147 and MMP-2 in 30 cases osteosarcoma and 10 cases osteochondroma. Results:The positive rate of CD147 and MMP-2 in osteosarcoma were obviously higher than that in osteochondroma. In osteosarcoma, the positive expression of CD147 and MMP-2 had relations with Enneking stage and pulmonary metastasis;moreover, in osteosarcoma, expression of CD147 was positively related with MMP-2. Conclusions:CD147 and MMP-2 play important role in inifltration and metastasis of osteosarcoma. Joint detection of CD147 and MMP-2 is expected to become a new index for judging the prognosis of osteosarcoma.