承德医学院学报
承德醫學院學報
승덕의학원학보
JOURNAL OF CHENGDE MEDICAL
2013年
6期
453-455
,共3页
大肠癌%谷胱甘肽-巯基-转移酶-π%P-糖蛋白%免疫组织化学
大腸癌%穀胱甘肽-巰基-轉移酶-π%P-糖蛋白%免疫組織化學
대장암%곡광감태-구기-전이매-π%P-당단백%면역조직화학
Colorectal carcinoma%Glutathione-s-transferase-π(GST-π)%P-glycoprotein (P-gp)%Immunohistochemistry
目的:研究大肠癌谷胱甘肽-巯基-转移酶-π(GST-π)和P-糖蛋白(P-gp)的表达情况及二者与大肠癌临床病理特征的关系。方法:应用免疫组织化学S-P法检测86例大肠癌组织和52例远端正常组织(距癌灶>10cm)GST-π和P-gp的表达情况,并分析二者与大肠癌临床病理特征的关系。结果:大肠癌组织GST-π和P-gp的阳性表达率均明显高于远端正常组织(P<0.01,P<0.05)。大肠癌组织P-gp表达与淋巴结转移有关,有淋巴结转移者P-gp阳性表达率明显高于无淋巴转移者(P<0.05)。大肠癌GST-π和P-gp的表达呈正相关(P<0.01)。结论:GST-π、P-gp在大肠癌中的高表达可能与大肠癌原发性多药耐药有关,临床联合检测GST-π和P-gp可为制定合理的个体化化疗方案提供理论依据。
目的:研究大腸癌穀胱甘肽-巰基-轉移酶-π(GST-π)和P-糖蛋白(P-gp)的錶達情況及二者與大腸癌臨床病理特徵的關繫。方法:應用免疫組織化學S-P法檢測86例大腸癌組織和52例遠耑正常組織(距癌竈>10cm)GST-π和P-gp的錶達情況,併分析二者與大腸癌臨床病理特徵的關繫。結果:大腸癌組織GST-π和P-gp的暘性錶達率均明顯高于遠耑正常組織(P<0.01,P<0.05)。大腸癌組織P-gp錶達與淋巴結轉移有關,有淋巴結轉移者P-gp暘性錶達率明顯高于無淋巴轉移者(P<0.05)。大腸癌GST-π和P-gp的錶達呈正相關(P<0.01)。結論:GST-π、P-gp在大腸癌中的高錶達可能與大腸癌原髮性多藥耐藥有關,臨床聯閤檢測GST-π和P-gp可為製定閤理的箇體化化療方案提供理論依據。
목적:연구대장암곡광감태-구기-전이매-π(GST-π)화P-당단백(P-gp)적표체정황급이자여대장암림상병리특정적관계。방법:응용면역조직화학S-P법검측86례대장암조직화52례원단정상조직(거암조>10cm)GST-π화P-gp적표체정황,병분석이자여대장암림상병리특정적관계。결과:대장암조직GST-π화P-gp적양성표체솔균명현고우원단정상조직(P<0.01,P<0.05)。대장암조직P-gp표체여림파결전이유관,유림파결전이자P-gp양성표체솔명현고우무림파전이자(P<0.05)。대장암GST-π화P-gp적표체정정상관(P<0.01)。결론:GST-π、P-gp재대장암중적고표체가능여대장암원발성다약내약유관,림상연합검측GST-π화P-gp가위제정합리적개체화화료방안제공이론의거。
Objective:To study the expression of glutathione-s-transferase-π(GST-π) and P-glycoprotein (P-gp) in human colorectal cancer and their relationships with clinical pathological characteristics of colorectal cancer. Methods:S-P immunohistochemical staining was used to detect the expression of GST-πand P-gp in 86 cases colorectal cancer and 52 cases distal normal tissue (>10cm from the cancer). And the correlations between GST-π, P-gp expression and the clinical pathological characteristics of colorectal cancer were analyzed.Results:The positive expression rate of GST-πand P-gp in colorectal cancer were all signiifcantly higher than that in distal normal tissues (P<0.01, P<0.05). The expression of P-gp in colorectal cancer was related with lymph node metastasis:the positive expression rate of P-gp of patients with lymph node metastasis was signiifcantly higher than that no lymph node metastasis (P<0.05). There had positive correlation between GST-πand P-gp expression in colorectal cancer (P<0.01). Conclusions: High expression of GST-πand P-gp in colorectal cancer may be associated with primary multidrug resistance of the cancer. Joint detection of GST-πand P-gp in clinic can provide theoretical basis for reasonable individual chemotherapy scheme.