CAJ | 학술논문

目的：探讨特发性畸形精子症药物治疗效果及与治疗时间的关系。方法回顾性选择2011年9月至2013年4月就诊于吉林大学第二医院生殖医学中心男科门诊确诊为特发性畸形精子症、予以VC+VE+叶酸+左旋肉碱+十一酸睾酮方案治疗的患者，共228例，收集治疗前、治疗3个月后和（或）6个月后正常形态精子百分比，并予以统计学分析。结果治疗3个月后，有效率68.32%，正常形态精子百分比较治疗前明显提高（P＜0.05）；治疗6个月后，有效率81.99%，正常形态精子百分比较治疗前明显提高（P＜0.05）；连续治疗6个月比治疗3个月正常形态精子百分比提高更明显，差异有统计学意义（P＜0.05）。结论维生素C+维生素E+叶酸+左旋肉碱+十一酸睾酮方案可提高正常形态精子百分比；治疗6个月效果优于3个月。
목적：탐토특발성기형정자증약물치료효과급여치료시간적관계。방법회고성선택2011년9월지2013년4월취진우길림대학제이의원생식의학중심남과문진학진위특발성기형정자증、여이VC+VE+협산+좌선육감+십일산고동방안치료적환자，공228례，수집치료전、치료3개월후화（혹）6개월후정상형태정자백분비，병여이통계학분석。결과치료3개월후，유효솔68.32%，정상형태정자백분비교치료전명현제고（P＜0.05）；치료6개월후，유효솔81.99%，정상형태정자백분비교치료전명현제고（P＜0.05）；련속치료6개월비치료3개월정상형태정자백분비제고경명현，차이유통계학의의（P＜0.05）。결론유생소C+유생소E+협산+좌선육감+십일산고동방안가제고정상형태정자백분비；치료6개월효과우우3개월。
Objective To investigate the relationship between clinical efficacy of the drug and its treatment time for patients with diopathic teratospermia. Methods Total of 228 patients with idiopathic teratospermia who were treated with VC+VE+ folic acid+ l-carnitine + undecanoic acid testosterone therapy in the Reproductive Center of the Second Hospital of Jilin University from Sep.2011 to Apr. 2013 were retrospectively reviewed. The percentages of normal sperm morphology before treatment and after 3 and/or 6 months treatment were statistically analzyed. Results After 3 months treatment, the effective rate was 68.32%, it was obviously improved in the percentage of normal morphology sperm compared to that of pre-treatment (P<0.05). After 6 months treatment, the effective rate was 81.99%, it was obviously improved in the percentage of normal morphology sperm compared to that of pre-treatment(P<0.05).There was significant different in the percentage of normal morphology sperm between patients treated for 6 months and patients treated for 3 months (P<0.05). Conclusion VC+VE+folicacid+l-carnitine+ undecanoic acid testosterone therapy can obviously improve the percenrage of normal morphology sperm in patients with idiopathic teratospermia. Efficacy of long term treatment (6 months) is superior to that of short term treatment (3 months).