CAJ | 학술논문

背景与目的：结直肠癌根治性手术后复发率达30%~40%，肿瘤复发影响患者生存时间。本研究旨在探讨结直肠癌复发时间(time to relapse，TTR)与肿瘤临床病理参数的关系，并进一步分析TTR对复发后生存时间的影响。方法：分析辽宁省肿瘤医院收治的375例结直肠癌患者的临床资料、病理结果及随访数据，比较结直肠癌复发与临床资料和病理类型的相关性，并研究TTR与复发后总体生存时间的关系。结果：TTR与确诊时肿瘤分期以及有无肺、肝脏转移密切相关。短期复发(<2年)与生存时间密切相关，2~5年内复发与5年以上复发的患者，其生存时间差异无统计学意义(P>0.05)。结论：结直肠癌患者术后复发时间与肿瘤分期及有无肺、肝脏转移密切相关，短期复发是预测复发后生存时间的重要指标。
배경여목적：결직장암근치성수술후복발솔체30%~40%，종류복발영향환자생존시간。본연구지재탐토결직장암복발시간(time to relapse，TTR)여종류림상병리삼수적관계，병진일보분석TTR대복발후생존시간적영향。방법：분석요녕성종류의원수치적375례결직장암환자적림상자료、병리결과급수방수거，비교결직장암복발여림상자료화병리류형적상관성，병연구TTR여복발후총체생존시간적관계。결과：TTR여학진시종류분기이급유무폐、간장전이밀절상관。단기복발(<2년)여생존시간밀절상관，2~5년내복발여5년이상복발적환자，기생존시간차이무통계학의의(P>0.05)。결론：결직장암환자술후복발시간여종류분기급유무폐、간장전이밀절상관，단기복발시예측복발후생존시간적중요지표。
Background and purpose:The risk of recurrence for colorectal cancer after curative surgery is up to 30%-40%. We aimed to evaluate the relationship between time to relapse (TTR) of colorectal cancer with clinical pathological parameters and overall survival after recurrence. Methods:We carried out the analysis of clinical data, pathological examination and follow up information of 375 colorectal cancer patients who admitted to Liaoning Cancer Hospital. Patients were categorized into relapse at<2, 2-5 and>5 years following their initial surgery. Results:TTR was associated with the clinical stage at diagnosis and liver or lung metastasis status. Short TTR (<2 years) was positively associated with survival. However, there was no significant difference in survival between patients who relapsed at 5 years or later compared with those who relapsed between 2 and 5 years. Conclusion:TTR within 2 years is an important predictor of shorter survival for colorectal cancer patients who experienced a relapse.