CAJ | 학술논문

目的：探讨糖尿病靶器官损害中的主要影响因素。方法检测糖尿病靶器官损害患者（ ODM组）56例和无糖尿病靶器官损害患者（ DM组）40例。采用全自动化学免疫发光法检测尿微量蛋白，计算尿白蛋白排泄率（UAER），采用全自动血凝仪测定D-二聚体（D-Dimer，D-D），采用散射比浊法检测血清超敏C反应蛋白（ hs-CRP）水平。应用彩色多普勒检测心脏及颈总动脉，测量颈总动脉内-中膜厚度（ IMT）和左室重量指数（ LVMI）。以检查结果异常作为判断糖尿病靶器官损害的指标并比较两组性别、年龄、病程、糖化血红蛋白（HbA1c）、总胆固醇（TC）、甘油三酯（TG）、低密度脂蛋白胆固醇（LDL-C）、高血压。结果病程、年龄、HbA1c、TC、TG、LDL-C、高血压、UAER、hs-CRP、D-D在糖尿病靶器官损害患者中指标增高，与DM组比较差异有统计学意义（ P＜0.01）。经多因素Logistic逐步回归分析显示，LDL-C、hs-CRP对糖尿病靶器官的损害有明显影响（ P＜0.05）。结论 LDL-C、hs-CRP与糖尿病靶器官损害的发生、发展密切相关，可作为判断糖尿病预后及治疗效果的参考指标。
목적：탐토당뇨병파기관손해중적주요영향인소。방법검측당뇨병파기관손해환자（ ODM조）56례화무당뇨병파기관손해환자（ DM조）40례。채용전자동화학면역발광법검측뇨미량단백，계산뇨백단백배설솔（UAER），채용전자동혈응의측정D-이취체（D-Dimer，D-D），채용산사비탁법검측혈청초민C반응단백（ hs-CRP）수평。응용채색다보륵검측심장급경총동맥，측량경총동맥내-중막후도（ IMT）화좌실중량지수（ LVMI）。이검사결과이상작위판단당뇨병파기관손해적지표병비교량조성별、년령、병정、당화혈홍단백（HbA1c）、총담고순（TC）、감유삼지（TG）、저밀도지단백담고순（LDL-C）、고혈압。결과병정、년령、HbA1c、TC、TG、LDL-C、고혈압、UAER、hs-CRP、D-D재당뇨병파기관손해환자중지표증고，여DM조비교차이유통계학의의（ P＜0.01）。경다인소Logistic축보회귀분석현시，LDL-C、hs-CRP대당뇨병파기관적손해유명현영향（ P＜0.05）。결론 LDL-C、hs-CRP여당뇨병파기관손해적발생、발전밀절상관，가작위판단당뇨병예후급치료효과적삼고지표。
Objective To explore the main influence factors of the target organ damage in the diabetes pa-tients.Methods Fifty-six diabetes patients with target organ damage ( ODM group) and 40 diabetes patients without with target organ damage (DM group) were detected.The urine micro protein was tested with automatic chemical im-mune luminescence method and the albumin excretion rate ( UAER) was calculated .D-D was detected with fully auto-matic blood coagulation analyzer and serum hs-CRP levels with scattering turbidimetric method .Color doppler ultra-sound was used for detecting common carotid artery intima-media thickness ( IMT) and left ventricular mass index (LVMI).The detected abnormal results were used as indexes of target organ damage in the diabetes patients and the two groups were compared of gender , age, course, glycosylated hemoglobin(HbA1c), total cholesterol(TC), triglyc-erides(TG), low density lipoprotein cholesterol (LDL-C), hypertension.Results Course,age, HbA1c,TC,TG, LDL-C, hypertension , UAER, hs -CRP, D-D were increased in ODM group , compared with DM group ,the differ-ence between two group were statistically significant ( P<0.01 ) .The multi-factor Logistic stepwise regression analysis showed that LDL-C、hs-CRP had significant effect on the target organ damage in diabetes patients ( P<0.05 ) .Con-clusion LDL-C,hs-CRP are closely related to the occurrence and development of target organ damage in diabetes pa -tients, and can be used as reference indexes for evaluating prognosis and therapeutic effect of diabetes .