CAJ | 학술논문

目的：探讨晚期鼻咽癌患者对EB病毒晚期潜伏膜蛋白（ EBV-LMP）的特异性细胞免疫应答问题。方法提取鼻咽癌患者自体单个核细胞体外培养，加入EBV-LMP2抗原制成致敏淋巴细胞，致敏淋巴细胞经患者皮内注射，观察其细胞免疫指标水平的变化。结果经致敏淋巴细胞注射后的鼻咽癌患者其EB病毒特异性细胞免疫水平随注射次数的增加而明显增高。结论鼻咽癌患者特异性细胞免疫治疗可作为鼻咽癌治疗的有效辅助手段。
목적：탐토만기비인암환자대EB병독만기잠복막단백（ EBV-LMP）적특이성세포면역응답문제。방법제취비인암환자자체단개핵세포체외배양，가입EBV-LMP2항원제성치민림파세포，치민림파세포경환자피내주사，관찰기세포면역지표수평적변화。결과경치민림파세포주사후적비인암환자기EB병독특이성세포면역수평수주사차수적증가이명현증고。결론비인암환자특이성세포면역치료가작위비인암치료적유효보조수단。
Objective To probe into specific cellular immunity to EBV-LMP in advanced nasopharyngeal carcinoma patients .Methods Peripheral blood mononuclear cell drawn from nasopharyngeal carcinoma patients were cultured in vitro.EBV-LMP2 was added to prepare sensitized lymphocytes cells , which was injected into patients . Change in specific cellular immunity level was observed .Results With sensitized lymphocytes cell injected specific cellular immunity level increased in nasopharyngeal carcinoma patients .Conclusion Specific cellular immunity cure can be effective adjuvant therapy to the nasopharyngeal carcinoma patients .