河南医学研究
河南醫學研究
하남의학연구
HENAN MEDICAL RESEARCH
2014年
9期
8-11
,共4页
王梦歌%欧阳松云%孙培宗
王夢歌%歐暘鬆雲%孫培宗
왕몽가%구양송운%손배종
慢性充血性心力衰竭%潮式呼吸-中枢性睡眠呼吸暂停%无创正压通气
慢性充血性心力衰竭%潮式呼吸-中樞性睡眠呼吸暫停%無創正壓通氣
만성충혈성심력쇠갈%조식호흡-중추성수면호흡잠정%무창정압통기
chronic heart failure%cheyne stokes respiration-central sleep apnea%positive-pressure respiration
目的:探讨无创正压通气( noninvasive positive pressure ventilation ,NPPV)治疗对慢性充血性心力衰竭(chronic heart failure,CHF)合并潮式呼吸(cheyne-stokes respiration,CSR)-中枢性睡眠呼吸暂停(central sleep apnea,CSA)患者的影响。方法:回顾性分析67例CHF合并CSR-CSA患者,根据治疗方案不同分为NPPV组(34例)和对照组(33例),对照组单纯行常规抗心衰药物治疗,NPPV组在常规抗心衰药物治疗基础上加用NPPV,治疗6个月复查。结果:①NPPV组治疗前后比较,BMI、ESS评分、呼吸暂停低通气指数( AHI)、微觉醒指数均明显下降(P<0.05);Ⅲ期及快速动眼期睡眠时间、最低血氧饱和度(L-SaO2)明显增加(P<0.05)。②治疗后,NPPV组纽约心功能分级( NYHA)、B 型脑钠肽( BNP)均较前降低,左心室射血分数(LVEF)、6 min步行距离较前增加,差异有统计学意义(P<0.05)。结论:对CHF合并CSR-CSA患者,在常规应用抗心衰药物治疗基础上积极采用NPPV治疗,可更大程度地改善心脏功能,值得临床推广应用。
目的:探討無創正壓通氣( noninvasive positive pressure ventilation ,NPPV)治療對慢性充血性心力衰竭(chronic heart failure,CHF)閤併潮式呼吸(cheyne-stokes respiration,CSR)-中樞性睡眠呼吸暫停(central sleep apnea,CSA)患者的影響。方法:迴顧性分析67例CHF閤併CSR-CSA患者,根據治療方案不同分為NPPV組(34例)和對照組(33例),對照組單純行常規抗心衰藥物治療,NPPV組在常規抗心衰藥物治療基礎上加用NPPV,治療6箇月複查。結果:①NPPV組治療前後比較,BMI、ESS評分、呼吸暫停低通氣指數( AHI)、微覺醒指數均明顯下降(P<0.05);Ⅲ期及快速動眼期睡眠時間、最低血氧飽和度(L-SaO2)明顯增加(P<0.05)。②治療後,NPPV組紐約心功能分級( NYHA)、B 型腦鈉肽( BNP)均較前降低,左心室射血分數(LVEF)、6 min步行距離較前增加,差異有統計學意義(P<0.05)。結論:對CHF閤併CSR-CSA患者,在常規應用抗心衰藥物治療基礎上積極採用NPPV治療,可更大程度地改善心髒功能,值得臨床推廣應用。
목적:탐토무창정압통기( noninvasive positive pressure ventilation ,NPPV)치료대만성충혈성심력쇠갈(chronic heart failure,CHF)합병조식호흡(cheyne-stokes respiration,CSR)-중추성수면호흡잠정(central sleep apnea,CSA)환자적영향。방법:회고성분석67례CHF합병CSR-CSA환자,근거치료방안불동분위NPPV조(34례)화대조조(33례),대조조단순행상규항심쇠약물치료,NPPV조재상규항심쇠약물치료기출상가용NPPV,치료6개월복사。결과:①NPPV조치료전후비교,BMI、ESS평분、호흡잠정저통기지수( AHI)、미각성지수균명현하강(P<0.05);Ⅲ기급쾌속동안기수면시간、최저혈양포화도(L-SaO2)명현증가(P<0.05)。②치료후,NPPV조뉴약심공능분급( NYHA)、B 형뇌납태( BNP)균교전강저,좌심실사혈분수(LVEF)、6 min보행거리교전증가,차이유통계학의의(P<0.05)。결론:대CHF합병CSR-CSA환자,재상규응용항심쇠약물치료기출상적겁채용NPPV치료,가경대정도지개선심장공능,치득림상추엄응용。
Objective:To investigate the effect of noninvasive positive pressure ventilation on pa-tients with chronic congestive heart failure combined with cheyne-stokes respiration and central sleep apnea .Methods:67 patients with CHF combined with CSR-CSA were divided into NPPV group(34 cases) and control group (33 cases) according to the different therapeutic regimens . The NPPV group was treated with standard medications and NPPV , and the control group was trea-ted with standard medications.Results:①NPPV group’s BMI, ESS score, AHI, arousal index after treatment were lower than before treatment ( P<0.05 ) , lowest oxygen saturation ( L-SaO 2) were increased in Ⅲperiod and not rapid eye movement ( NREM) ( P<0.05) .②NYHA, BNP of NPPV group was reduced and lower than before treatment ( P<0.05 ) , LVEF was higher ( P<0 .05 ) , the difference was statistically significant .Conclusion: For patients with CHF combined with CSR-CSA, NPPV could improve the heart function and deserve the clinical expansion .