郑州大学学报(医学版)
鄭州大學學報(醫學版)
정주대학학보(의학판)
JOURNAL OF ZHENGZHOU UNIVERSITY(MEDICAL SCIENCES)
2014年
4期
568-570,571
,共4页
CYP2 C19%基因多态性%氯吡格雷%河南省%冠心病
CYP2 C19%基因多態性%氯吡格雷%河南省%冠心病
CYP2 C19%기인다태성%록필격뢰%하남성%관심병
CYP2C19%genetic polymorphism%clopidogrel%Henan Province%coronary artery disease
目的:研究河南冠心病患者氯吡格雷代谢相关基因CYP2C19基因多态性的分布。方法:采用PCR-RFLP技术检测600名来自河南的冠心病患者CYP2C19的基因型。结果:CYP2C19倡1/倡1占42.6%、CYP2C19倡1/倡2占40.9%、CYP2C19倡1/倡3占6.5%、CYP2C19倡2/倡2占7.2%、CYP2C19倡2/倡3占2.5%、CYP2C19倡3/倡3占0.3%。结论:河南省人群CYP2 C19基因多态性的分布与全国其他地区基本一致。
目的:研究河南冠心病患者氯吡格雷代謝相關基因CYP2C19基因多態性的分佈。方法:採用PCR-RFLP技術檢測600名來自河南的冠心病患者CYP2C19的基因型。結果:CYP2C19倡1/倡1佔42.6%、CYP2C19倡1/倡2佔40.9%、CYP2C19倡1/倡3佔6.5%、CYP2C19倡2/倡2佔7.2%、CYP2C19倡2/倡3佔2.5%、CYP2C19倡3/倡3佔0.3%。結論:河南省人群CYP2 C19基因多態性的分佈與全國其他地區基本一緻。
목적:연구하남관심병환자록필격뢰대사상관기인CYP2C19기인다태성적분포。방법:채용PCR-RFLP기술검측600명래자하남적관심병환자CYP2C19적기인형。결과:CYP2C19창1/창1점42.6%、CYP2C19창1/창2점40.9%、CYP2C19창1/창3점6.5%、CYP2C19창2/창2점7.2%、CYP2C19창2/창3점2.5%、CYP2C19창3/창3점0.3%。결론:하남성인군CYP2 C19기인다태성적분포여전국기타지구기본일치。
To survey the genetic polymorphism of CYP 2C19 gene in the patients with coronary artery disease from Henan Province.Methods:The CYP2C19 genotypes of 600 patients with coronary artery disease from Henan Prov-ince were determined by PCR-RFLP.Results:The frequencies of CYP2C19*1/*1,*1/*2,*1/*3,*2/*2,*2/*3 and *3/*3 were 42.6%,40.9%,6.5%,7.2%,2.5%and 0.3%,respectively.Conclusion:There are no signifi-cant differences in the distribution of CYP 2C19 polymorphism between Henan and other areas of China .