CAJ | 학술논문

目的：探讨河南农村成年居民酪酪肽（ PYY）基因rs2880416位点多态性与肥胖易感性的关系。方法：抽取河南省某农村地区18岁以上的肥胖和非肥胖居民各410名，进行血液生化指标测定、体格检查及PYY基因rs2880416位点多态性检测。结果：共检出PYY基因rs2880416位点2个等位基因（ G和C）及3种基因型（ GG、CC、CG），肥胖和非肥胖组等位基因频率和基因型频率分布差异均有统计学意义（χ2＝53．110和56．842，P＜0．001），肥胖组C等位基因频率高于非肥胖组（P＜0．001）。经调整体育锻炼情况，在隐性模型中，CC型携带者肥胖的患病风险是GG/CG型携带者的2．327倍（OR＝2．327，95％CI＝1．338～4．047）；在显性模型中，CC/CG型携带者肥胖的患病风险是GG型携带者的3．013倍（OR＝3．013，95％CI＝2．257～4．023）；在相加模型中，C等位基因携带者肥胖的患病风险增加1．337倍（OR＝2．337，95％CI＝1．845～2．961）。肥胖组不同基因型携带者BMI、腰围、腰围身高比差异均无统计学意义（F＝1．931、0．235、0．115，P均＞0．05）。结论：PYY基因rs2880416位点C等位基因可能是河南农村成年居民肥胖发生的危险因素。
목적：탐토하남농촌성년거민락락태（ PYY）기인rs2880416위점다태성여비반역감성적관계。방법：추취하남성모농촌지구18세이상적비반화비비반거민각410명，진행혈액생화지표측정、체격검사급PYY기인rs2880416위점다태성검측。결과：공검출PYY기인rs2880416위점2개등위기인（ G화C）급3충기인형（ GG、CC、CG），비반화비비반조등위기인빈솔화기인형빈솔분포차이균유통계학의의（χ2＝53．110화56．842，P＜0．001），비반조C등위기인빈솔고우비비반조（P＜0．001）。경조정체육단련정황，재은성모형중，CC형휴대자비반적환병풍험시GG/CG형휴대자적2．327배（OR＝2．327，95％CI＝1．338～4．047）；재현성모형중，CC/CG형휴대자비반적환병풍험시GG형휴대자적3．013배（OR＝3．013，95％CI＝2．257～4．023）；재상가모형중，C등위기인휴대자비반적환병풍험증가1．337배（OR＝2．337，95％CI＝1．845～2．961）。비반조불동기인형휴대자BMI、요위、요위신고비차이균무통계학의의（F＝1．931、0．235、0．115，P균＞0．05）。결론：PYY기인rs2880416위점C등위기인가능시하남농촌성년거민비반발생적위험인소。
To explore the relationship between polymorphisms of the peptide YY ( PYY) gene rs2880416 site and obesity susceptibility in Henan rural adults .Methods: A total of 410 cases of obesity and 410 cases without obesity were selected in a certain rural area of Henan to test the physical indicators , blood biochemical indicators and the rs2880416 polymorphism.Results:Two alleles including C and G , and three genotypes including CC ,CG and GG, were detected, and there were significant differences in allele frequency and genotype frequency distribution between the two groups(χ2 =53.110 and 56.842,P<0.001);the C allele frequency in obesity group was higher (P<0.001).Based on that the physical exercise was adjusted , in the recessive model , the obesity risk of CC genotype carriers was 2.327 times the GG/CG carriers (OR=2.327, 95%CI=1.338-4.047);in the dominant model, that of the CC/CG genotype carri-ers was 3.013 times the GG carriers (OR=3.013, 95%CI=2.257-4.023);in the additive model, that of the C allele carriers increased 1.337-fold in turn(OR=2.337, 95%CI=1.845-2.961).The differences in BMI,waist circumfer-ence, or waist-to-height were not statistically significant among the 3 genotype carriers in obesity group (F=1.931,0.235, 0.115,P>0.05).Conclusion:The C allele of rs2880416 site in peptide YY gene is susceptible for obesity .