郑州大学学报（医学版）
鄭州大學學報（醫學版）
정주대학학보（의학판）
JOURNAL OF ZHENGZHOU UNIVERSITY(MEDICAL SCIENCES)
2014年
4期
536-539
,共4页
马蕴青%贺彩红%连亚军%陈媛%张海峰%谢南昌%吴川杰%郑亚珂%张璐%张毅
馬蘊青%賀綵紅%連亞軍%陳媛%張海峰%謝南昌%吳川傑%鄭亞珂%張璐%張毅
마온청%하채홍%련아군%진원%장해봉%사남창%오천걸%정아가%장로%장의
三叉神经痛%A型肉毒毒素%焦虑%抑郁%睡眠障碍
三扠神經痛%A型肉毒毒素%焦慮%抑鬱%睡眠障礙
삼차신경통%A형육독독소%초필%억욱%수면장애
trigeminal neuralgia%botulinum toxin type A%anxiety%depression%sleep interference
目的：观察3种剂量A型肉毒毒素治疗三叉神经痛的疗效，焦虑、抑郁、睡眠变化及其不良反应。方法：选取原发性三叉神经痛患者87例，随机分为25 U/mL组（28例）、50 U/mL组（31例）和75 U/mL组（28例）3种剂量组，分别于疼痛部位多点皮内注射不同剂量的A型肉毒毒素，对每位患者治疗前及治疗后8周内每周进行视觉模拟（ VAS）评分、焦虑评分、抑郁评分、睡眠干扰评分，并于第8周进行患者总体印象改变评分，观察疗效及其安全性。结果：3组治疗后疼痛治疗有效率差异无统计学意义（χ2＝3．482，P＝0．175）。治疗后3组焦虑、抑郁和睡眠评分均较各自治疗前显著降低，但3组有效率比较差异无统计学意义。治疗后3组患者总体印象改变改善率差异无统计学意义（χ2＝1．345，P＝0．510）。7例出现注射部位短暂性的肌肉松弛，2例出现注射部位肿胀，均自行消失，未进行处理，未见全身性不良反应。结论：不同剂量A型肉毒毒素治疗三叉神经痛均有效。
目的：觀察3種劑量A型肉毒毒素治療三扠神經痛的療效，焦慮、抑鬱、睡眠變化及其不良反應。方法：選取原髮性三扠神經痛患者87例，隨機分為25 U/mL組（28例）、50 U/mL組（31例）和75 U/mL組（28例）3種劑量組，分彆于疼痛部位多點皮內註射不同劑量的A型肉毒毒素，對每位患者治療前及治療後8週內每週進行視覺模擬（ VAS）評分、焦慮評分、抑鬱評分、睡眠榦擾評分，併于第8週進行患者總體印象改變評分，觀察療效及其安全性。結果：3組治療後疼痛治療有效率差異無統計學意義（χ2＝3．482，P＝0．175）。治療後3組焦慮、抑鬱和睡眠評分均較各自治療前顯著降低，但3組有效率比較差異無統計學意義。治療後3組患者總體印象改變改善率差異無統計學意義（χ2＝1．345，P＝0．510）。7例齣現註射部位短暫性的肌肉鬆弛，2例齣現註射部位腫脹，均自行消失，未進行處理，未見全身性不良反應。結論：不同劑量A型肉毒毒素治療三扠神經痛均有效。
목적：관찰3충제량A형육독독소치료삼차신경통적료효，초필、억욱、수면변화급기불량반응。방법：선취원발성삼차신경통환자87례，수궤분위25 U/mL조（28례）、50 U/mL조（31례）화75 U/mL조（28례）3충제량조，분별우동통부위다점피내주사불동제량적A형육독독소，대매위환자치료전급치료후8주내매주진행시각모의（ VAS）평분、초필평분、억욱평분、수면간우평분，병우제8주진행환자총체인상개변평분，관찰료효급기안전성。결과：3조치료후동통치료유효솔차이무통계학의의（χ2＝3．482，P＝0．175）。치료후3조초필、억욱화수면평분균교각자치료전현저강저，단3조유효솔비교차이무통계학의의。치료후3조환자총체인상개변개선솔차이무통계학의의（χ2＝1．345，P＝0．510）。7례출현주사부위단잠성적기육송이，2례출현주사부위종창，균자행소실，미진행처리，미견전신성불량반응。결론：불동제량A형육독독소치료삼차신경통균유효。
To observe the efficacy, anxiety, depression, sleep interference and adverse reaction of botulinum toxin type A ( BTX-A) with three doses for the treatment of trigeminal neuralgia .Methods:Eighty seven patients with tri-geminal neuralgia were randomized into three dose groups:BTX-A 25 U/mL(n=28), BTX-A 50 U/mL (n=31), BTX-A 75 U/mL(n=28) and local multi-point injection of different doses of BTX-A was administrated.Follow-up visits were conducted every week after the injection ,and the overall duration of the study for each patient was 8 weeks to observe the visual analogue scale (VAS), anxiety, depression and sleep interference score and the patient global impression of change ( PGIC) scale at endpoint , assessing the efficacy and safety .Results:There was no significant difference in VAS efficacy among three groups(χ2 =3.482,P=0.175).The scores of anxiety, depression and sleep interference of three groups re-duced significantly compared to baseline screening period , but there were no significant differences among three groups . There were no significant differences in PGIC among three groups (χ2 =1.345,P=0.510).Seven patients experienced transient muscle relaxation and two patients experienced edema in the injection area .All adverse reaction disappeared auto-matically without treatment , and there was no systemic adverse reaction .Conclusion:Three different doses of BTX-A for treatment of trigeminal neuralgia were all efficient , and there were no significant differences in multiple observation indexes among three groups .
