癌变·畸变·突变
癌變·畸變·突變
암변·기변·돌변
CARCINOGENSES,TERATOGENSIS AND MUTAGENESIS
2014年
4期
270-273
,共4页
芮萌%方庭正%段蕴铀%张新红
芮萌%方庭正%段蘊鈾%張新紅
예맹%방정정%단온유%장신홍
老年%肺癌%改良老年疾病累计评分表%预后
老年%肺癌%改良老年疾病纍計評分錶%預後
노년%폐암%개량노년질병루계평분표%예후
elderly%lung cancer%MCIRS-G%prognosis
目的：探讨影响70岁以上老年肺癌患者预后生存的危险因素。方法：随访分析62例70岁以上肺癌患者临床资料，计算改良老年疾病累计评分表(MCIRS-G)评分，得到总分(TSC)、严重指数(SV)和合并症指数(CM)。应用单因素分析及COX多因素回归模型分析确定影响预后的因素。结果：62例患者中位生存期为30.52个月，82.26%伴有合并症，TSC、CM、SV与年龄增长正相关(r依次为0.656、0.739、0.677，P均<0.05)。单因素分析显示年龄、病理类型、临床分期、美国东部肿瘤协作组(ECOG)评分、分化程度、手术、TSC、CM、SV与预后相关( P均<0.05)。COX多因素分析显示临床分期、ECOG评分、分化程度、手术、TSC、CM、SV是影响患者生存及预后的独立因素。结论：临床分期、分化程度、合并症、ECOG评分、手术是老年肺癌独立预后因子。MCIRS-G能有效评估合并症对老年肺癌患者预后的影响。
目的：探討影響70歲以上老年肺癌患者預後生存的危險因素。方法：隨訪分析62例70歲以上肺癌患者臨床資料，計算改良老年疾病纍計評分錶(MCIRS-G)評分，得到總分(TSC)、嚴重指數(SV)和閤併癥指數(CM)。應用單因素分析及COX多因素迴歸模型分析確定影響預後的因素。結果：62例患者中位生存期為30.52箇月，82.26%伴有閤併癥，TSC、CM、SV與年齡增長正相關(r依次為0.656、0.739、0.677，P均<0.05)。單因素分析顯示年齡、病理類型、臨床分期、美國東部腫瘤協作組(ECOG)評分、分化程度、手術、TSC、CM、SV與預後相關( P均<0.05)。COX多因素分析顯示臨床分期、ECOG評分、分化程度、手術、TSC、CM、SV是影響患者生存及預後的獨立因素。結論：臨床分期、分化程度、閤併癥、ECOG評分、手術是老年肺癌獨立預後因子。MCIRS-G能有效評估閤併癥對老年肺癌患者預後的影響。
목적：탐토영향70세이상노년폐암환자예후생존적위험인소。방법：수방분석62례70세이상폐암환자림상자료，계산개량노년질병루계평분표(MCIRS-G)평분，득도총분(TSC)、엄중지수(SV)화합병증지수(CM)。응용단인소분석급COX다인소회귀모형분석학정영향예후적인소。결과：62례환자중위생존기위30.52개월，82.26%반유합병증，TSC、CM、SV여년령증장정상관(r의차위0.656、0.739、0.677，P균<0.05)。단인소분석현시년령、병리류형、림상분기、미국동부종류협작조(ECOG)평분、분화정도、수술、TSC、CM、SV여예후상관( P균<0.05)。COX다인소분석현시림상분기、ECOG평분、분화정도、수술、TSC、CM、SV시영향환자생존급예후적독립인소。결론：림상분기、분화정도、합병증、ECOG평분、수술시노년폐암독립예후인자。MCIRS-G능유효평고합병증대노년폐암환자예후적영향。
This study aimed at evaluating the survival of patients older than 70 with lung cancer and explore the independent prognostic factors in this group of patients. METHODS:The modified cumulative illness rating scale-geriatric(MCIRS-G) was scored for a cohort of elderly patients with lung cancer. Total score (TSC),severity index(SV) and comorbidity index(CM) were obtained. Clinical features were also used. All patients underwent a follow-up for mortality. Univariate analysis and multivariate analysis were used to identify factors associated with prognosis in the enrolled patients. RESULTS:The overall median survival was 30.52 months and the incidence of complications was 82.26%. TSC,SV and CM were positively correlated with age(r were 0.656,0.739 and 0.677,respectively,P<0.05). By univariate analysis,age,pathological type,clinical stages,American Eastern Cooperative Oncology Group(ECOG) performance status (PS),differentiation degree,surgery,TSC,SV and CM were significantly related to prognosis and survival in geriatric lung cancer patients(P<0.05). By multivariable analysis,clinical stages,ECOG PS,differentiation degree,surgery,TSC,SV and CM were independent prognostic factors. CONCLUSION:Clinical stages,differentiation degree,comorbidity,ECOG PS and surgery may be independent prognostic factors in the elderly with lung cancer. The MCIRS-G could effectively assess the influence of comorbidities on the prognosis of lung cancer in this patient group.
