药学与临床研究
藥學與臨床研究
약학여림상연구
PHARMACEUTICAL AND CLINICAL RESEARCH
2014年
3期
222-225
,共4页
氯沙坦%慢性心衰%心血管%氧化应激
氯沙坦%慢性心衰%心血管%氧化應激
록사탄%만성심쇠%심혈관%양화응격
Losartan%CHF%Cardiovascular%Oxidative stress
目的：主要探讨氯沙坦对5/6肾切除慢性心衰模型大鼠心血管的影响。方法：雄性SD大鼠30只随机分为假手术组（Sham）、病理组（Nx）和氯沙坦治疗组（Lst）。 Nx组和Lst组行5/6肾切除术，Lst组于术后第7周初于饮水中连续两周给予氯沙坦（10 mg·kg-1·d-1）治疗。8周末处理所有大鼠，测定血流动力学参数、心指数、血管舒张度、血清肌酐、尿素氮以及心肌和血管组织中丙二醛（MDA）含量和超氧化物歧化酶（SOD）活性。结果：与Nx组比较，Lst组大鼠LVEDP降低，LVSP、LVDP绝对值升高，心指数降低，血管舒张度增大，血清中肌酐、尿素氮降低，各组织中MDA含量降低，SOD活性升高，结果有显著性差异或极显著性差异（P<0.05或P<0.01）。结论：氯沙坦能够改善慢性心衰大鼠左心肥厚、左心和血管内皮功能；降低心肌和血管组织中MDA含量并提高SOD活性，减轻组织氧化应激，对心血管产生有益作用。
目的：主要探討氯沙坦對5/6腎切除慢性心衰模型大鼠心血管的影響。方法：雄性SD大鼠30隻隨機分為假手術組（Sham）、病理組（Nx）和氯沙坦治療組（Lst）。 Nx組和Lst組行5/6腎切除術，Lst組于術後第7週初于飲水中連續兩週給予氯沙坦（10 mg·kg-1·d-1）治療。8週末處理所有大鼠，測定血流動力學參數、心指數、血管舒張度、血清肌酐、尿素氮以及心肌和血管組織中丙二醛（MDA）含量和超氧化物歧化酶（SOD）活性。結果：與Nx組比較，Lst組大鼠LVEDP降低，LVSP、LVDP絕對值升高，心指數降低，血管舒張度增大，血清中肌酐、尿素氮降低，各組織中MDA含量降低，SOD活性升高，結果有顯著性差異或極顯著性差異（P<0.05或P<0.01）。結論：氯沙坦能夠改善慢性心衰大鼠左心肥厚、左心和血管內皮功能；降低心肌和血管組織中MDA含量併提高SOD活性，減輕組織氧化應激，對心血管產生有益作用。
목적：주요탐토록사탄대5/6신절제만성심쇠모형대서심혈관적영향。방법：웅성SD대서30지수궤분위가수술조（Sham）、병리조（Nx）화록사탄치료조（Lst）。 Nx조화Lst조행5/6신절제술，Lst조우술후제7주초우음수중련속량주급여록사탄（10 mg·kg-1·d-1）치료。8주말처리소유대서，측정혈류동역학삼수、심지수、혈관서장도、혈청기항、뇨소담이급심기화혈관조직중병이철（MDA）함량화초양화물기화매（SOD）활성。결과：여Nx조비교，Lst조대서LVEDP강저，LVSP、LVDP절대치승고，심지수강저，혈관서장도증대，혈청중기항、뇨소담강저，각조직중MDA함량강저，SOD활성승고，결과유현저성차이혹겁현저성차이（P<0.05혹P<0.01）。결론：록사탄능구개선만성심쇠대서좌심비후、좌심화혈관내피공능；강저심기화혈관조직중MDA함량병제고SOD활성，감경조직양화응격，대심혈관산생유익작용。
Objevtives: To explore the cardiovascular effects of losartan in 5/6 nephrectomy rats with chronic heart failure (CHF). Methods: Thirty male SD (Sprague Dawley) rats were randomly divided into sham group(sham), pathology group(Nx) and losartan group(Lst). Nx group and Lst group were induced by 5/6 nephrectomy. Rats in the Lst group were given losatan (10 mg·kg-1·d-1) through drinking water from the beginning of the postoperative 7th week to the end of the 8th week. At the end of the 8th week, all rats were measured for hemodynamic parameters, cardiac index, vasodilation degrees, serum creatinine and urea nitrogen, and the malondialdehyde (MDA) contents and superoxide dismutase (SOD) activities in myocardium and aorta tissues. Results: Compared with the Nx group, rats in the Lst group had decreased LVEDP, cardiac index, serum urea nitrogen and creatinine, and tissue MDA content; and increased LVSP, LVDP, vasodilation and tissue SOD activity. The differences were significant or very significant (P<0.05 or P<0.01). Conclusion: Losartan can improve left ventricular hypertrophy and the left ventricular and vascular en-dothelial functions of rats with CHF. It also may have beneficial effects to the myocardium and aorta tis-sues by reducing tissue oxidative stress of CHF rats.
