中国基层医药
中國基層醫藥
중국기층의약
CHINESE JOURNAL OF PRIMARY MEDICINE AND PHARMACY
2014年
8期
1132-1134
,共3页
冠心病%脑钠肽%C反应蛋白质%冠脉造影
冠心病%腦鈉肽%C反應蛋白質%冠脈造影
관심병%뇌납태%C반응단백질%관맥조영
Coronary heart disease%Brain natriuretic peptide%C-reactive protein%intervention%Coronary angiography
目的 探讨介入治疗对老年冠心病患者脑钠肽和超敏C-反应蛋白(hsCRP)水平的影响.方法 选取130例接受介入治疗的老年冠状动脉造影患者为观察组,30例冠状动脉造影正常者为对照组.测定并比较46例急性心肌梗死(AMI)组、34例不稳定型心绞痛(UAP)组、50例稳定型心绞痛(SAP)组和30例冠状动脉造影正常对照组(NOR)的血浆hsCRP及脑钠肽(BNP)的差异.结果 冠心病组(AMI组、UAP组和SAP组)患者的BNP水平分别为(548.6±200.4) mg/L、(521.0±198.7) mg/L和(175.8±119.4) mg/L,均显著高于对照组的(59.3 ±45.7) mg/L,hsCRP水平只有在急性心肌梗死组及不稳定型心绞痛组明显升高,差异具有统计学意义(t=13.74、10.65,均P＜0.05).PCI术后3d和3个月,冠心病组hsCRP先升高到(45.8±15.3)ng/L,然后又降低到(8.6±4.4)ng/L,差异有统计学意义(t=10.76、14.54,均P＜0.05);而BNP水平则一直下降,先降到(247.4 ±70.1)mg/L,3个月后降到(69.8 ±20.0) mg/L,两者差异有统计学意义(t=11.47、19.64,均P＜0.05).结论 脑钠肽、hsCRP水平是反映冠心病患者冠状动脉内支架置入术后早期炎性反应及评估病情的敏感指标,其可能在支架置入术后再狭窄发生过程中发挥作用.
目的 探討介入治療對老年冠心病患者腦鈉肽和超敏C-反應蛋白(hsCRP)水平的影響.方法 選取130例接受介入治療的老年冠狀動脈造影患者為觀察組,30例冠狀動脈造影正常者為對照組.測定併比較46例急性心肌梗死(AMI)組、34例不穩定型心絞痛(UAP)組、50例穩定型心絞痛(SAP)組和30例冠狀動脈造影正常對照組(NOR)的血漿hsCRP及腦鈉肽(BNP)的差異.結果 冠心病組(AMI組、UAP組和SAP組)患者的BNP水平分彆為(548.6±200.4) mg/L、(521.0±198.7) mg/L和(175.8±119.4) mg/L,均顯著高于對照組的(59.3 ±45.7) mg/L,hsCRP水平隻有在急性心肌梗死組及不穩定型心絞痛組明顯升高,差異具有統計學意義(t=13.74、10.65,均P＜0.05).PCI術後3d和3箇月,冠心病組hsCRP先升高到(45.8±15.3)ng/L,然後又降低到(8.6±4.4)ng/L,差異有統計學意義(t=10.76、14.54,均P＜0.05);而BNP水平則一直下降,先降到(247.4 ±70.1)mg/L,3箇月後降到(69.8 ±20.0) mg/L,兩者差異有統計學意義(t=11.47、19.64,均P＜0.05).結論 腦鈉肽、hsCRP水平是反映冠心病患者冠狀動脈內支架置入術後早期炎性反應及評估病情的敏感指標,其可能在支架置入術後再狹窄髮生過程中髮揮作用.
목적 탐토개입치료대노년관심병환자뇌납태화초민C-반응단백(hsCRP)수평적영향.방법 선취130례접수개입치료적노년관상동맥조영환자위관찰조,30례관상동맥조영정상자위대조조.측정병비교46례급성심기경사(AMI)조、34례불은정형심교통(UAP)조、50례은정형심교통(SAP)조화30례관상동맥조영정상대조조(NOR)적혈장hsCRP급뇌납태(BNP)적차이.결과 관심병조(AMI조、UAP조화SAP조)환자적BNP수평분별위(548.6±200.4) mg/L、(521.0±198.7) mg/L화(175.8±119.4) mg/L,균현저고우대조조적(59.3 ±45.7) mg/L,hsCRP수평지유재급성심기경사조급불은정형심교통조명현승고,차이구유통계학의의(t=13.74、10.65,균P＜0.05).PCI술후3d화3개월,관심병조hsCRP선승고도(45.8±15.3)ng/L,연후우강저도(8.6±4.4)ng/L,차이유통계학의의(t=10.76、14.54,균P＜0.05);이BNP수평칙일직하강,선강도(247.4 ±70.1)mg/L,3개월후강도(69.8 ±20.0) mg/L,량자차이유통계학의의(t=11.47、19.64,균P＜0.05).결론 뇌납태、hsCRP수평시반영관심병환자관상동맥내지가치입술후조기염성반응급평고병정적민감지표,기가능재지가치입술후재협착발생과정중발휘작용.
Objective To investigate the effect of interventional treatment in coronary heart disease (CHD) in elderly patients with brain natriuretic peptide and high-sensitivity C-reactive protein (hsCRP) levels.Methods 130 elderly patients undergoing coronary angiography interventional treatment were selected for the observation group,30 cases with normal coronary arteries angiography were chosen as the control group.In 46 cases of acute myocardial infarction(AMI) group,34 cases of unstable angina pectoris(UAP) group and 50 patients with stable angina pectoris (SAP) group and 30 cases coronary angiography normal control group(NOR),the hs-CRP and plasma brain natriuretic peptide(BNP) differences were determined and compared.Results CHD (AMI group,UAP group and SAP group) in patients with BNP levels were (548.6 ± 200.4) mg/L,(521.0 ± 198.7) mg/L and (175.8 ± 119.4) mg/L,which were significantly higher (59.3 ± 45.7) mg/L in the control group,hsCRP levels only in patients with acute myocardial infarction and unstable angina was significantly increased,the difference was statistically significant (t =13.74,10.65,all P ＜ 0.05).3d after PCI and three months prior CHD hsCRP increased to (45.8 ± 15.3)ng/L,and then decreased to (8.6 ± 4.4) ng/L,significantly different (t =10.76,14.54,all P ＜ 0.05) ; while BNP levels have been falling,first down (247.4 ± 70.1)mg/L,3 months after the falls (69.8 ± 20.0)mg/L,the difference was significant(t =11.47,19.64,all P＜0.05).Conclusion The levels of brain natriuretic peptide,hsCRP are reflections of coronary stenting in patients with coronary heart disease early postoperative inflammatory reaction and evaluate a sensitive indicator of disease,which may play an role in stent restenosis occurs.
