CAJ | 학술논문

目的：评价喜炎平治疗手足口病的有效性和安全性。方法计算机检索Cochrane Library、PubMed、Medline、中国生物医学数据库（CBM）、中国期刊全文数据库（CNKI）、维普数据库（VIP）和万方数据知识服务平台，收集所有喜炎平对比利巴韦林治疗手足口病的随机对照试验。由2位评价员独立筛选合格文献并提取相关信息进行分析。根据Cochrane协作网推荐的“偏倚风险评估工具”进行偏倚风险评估，用Revman5.0软件进行统计学分析。结果最终纳入24篇随机对照试验，共3314例手足口病患儿。喜炎平组在总有效率、热退时间和疹退时间的疗效优于利巴韦林组，差异具有统计学意义(RR=1.17，95%CI：1.12~1.23；MD=-1.56，95%CI：-2.10~-1.02；MD=-1.41，95%CI：-1.90~-0.93）。两组中发生不良反应均较少，且在停药后均可恢复正常。结论目前证据表明，喜炎平治疗手足口病的疗效优于利巴韦林。
목적：평개희염평치료수족구병적유효성화안전성。방법계산궤검색Cochrane Library、PubMed、Medline、중국생물의학수거고（CBM）、중국기간전문수거고（CNKI）、유보수거고（VIP）화만방수거지식복무평태，수집소유희염평대비리파위림치료수족구병적수궤대조시험。유2위평개원독립사선합격문헌병제취상관신식진행분석。근거Cochrane협작망추천적“편의풍험평고공구”진행편의풍험평고，용Revman5.0연건진행통계학분석。결과최종납입24편수궤대조시험，공3314례수족구병환인。희염평조재총유효솔、열퇴시간화진퇴시간적료효우우리파위림조，차이구유통계학의의(RR=1.17，95%CI：1.12~1.23；MD=-1.56，95%CI：-2.10~-1.02；MD=-1.41，95%CI：-1.90~-0.93）。량조중발생불량반응균교소，차재정약후균가회복정상。결론목전증거표명，희염평치료수족구병적료효우우리파위림。
Objective To evaluate the efifcacy and safety of Xiyanping in the treatment of hand-foot and mouth disease. Methods Based on the principles and methods of Cochrane systematic reviews, Cochrane Library, PubMed, Medline, Chinese Bio-medicine Database (CBM), China Journal Full-text Database (CNKI), VIP database and Wanfang database were searched. All of the randomized controlled trials (RCT) of Xiyanping versus ribavirin were included. The data were extracted and evalu-ated by two reviewers independently. Risk assessment tool was used to assess the risk of bias and software Revman5.0 was used for meta-analysis. Results Twenty-four RCT and 3314 patients were included. Comparing to ribavirin, Xiyanping showed better therapeutic outcomes regarding to total effective rate, durations of fever and rash elimination (RR=1.17, 95%CI:1.12~1.23;MD=-1.56, 95%CI:-2.10~-1.02;MD=-1.41, 95%CI:-1.90~-0.93). Side effects were rare in both groups and could be recovered after drug withdrawal. Conclusions The current evidence suggests that Xiyanping is superior to ribavirin in the treatment of hand-foot and mouth disease.