CAJ | 학술논문

目的：系统评价载脂蛋白E（ApoE）基因多态性与儿童肥胖易感性的关联。方法通过计算机及手工全面检索PubMed、OVID、Science online、BMJ、Springer Link、超星Medlink、中国全文期刊数据库、万方数据库,检索1996年3月至2013年3月发表的关于ApoE基因单核苷酸多态性（SNPs）与儿童肥胖关联的病例对照研究，根据纳入排除标准，筛选文献，应用Rev Man 5.0软件对各纳入文献进行异质性检验及效应值合并，同时进行敏感性分析和偏倚估计。结果共检索到相关文献84篇，最终纳入符合条件的文献9篇，其中肥胖儿童767例，正常体质量儿童867例。根据异质性检验结果，对ApoE基因ε2、ε3、ε43种等位基因与儿童肥胖发生采用相应的效应模型进行合并分析。结果显示，相对正常体质量儿童，肥胖儿童携带ApoE基因ε2、ε3、ε43种等位基因的OR值（95%CI）分别为1.10（0.85，1.43）、0.66（0.55，0.80）、1.82（1.31，2.52），ε2等位基因在两组间的差异无统计学意义（P=0.45），ε3及ε4等位基因在两组间差异有统计学意义（P<0.001）。各研究的敏感性分析稳定较好，且漏斗图形基本对称。结论 ApoE基因多态性与儿童肥胖发生存在密切关系，其中携带ε3等位基因为儿童肥胖的保护因素，携带ε4等位基因为儿童肥胖的危险因素。
목적：계통평개재지단백E（ApoE）기인다태성여인동비반역감성적관련。방법통과계산궤급수공전면검색PubMed、OVID、Science online、BMJ、Springer Link、초성Medlink、중국전문기간수거고、만방수거고,검색1996년3월지2013년3월발표적관우ApoE기인단핵감산다태성（SNPs）여인동비반관련적병례대조연구，근거납입배제표준，사선문헌，응용Rev Man 5.0연건대각납입문헌진행이질성검험급효응치합병，동시진행민감성분석화편의고계。결과공검색도상관문헌84편，최종납입부합조건적문헌9편，기중비반인동767례，정상체질량인동867례。근거이질성검험결과，대ApoE기인ε2、ε3、ε43충등위기인여인동비반발생채용상응적효응모형진행합병분석。결과현시，상대정상체질량인동，비반인동휴대ApoE기인ε2、ε3、ε43충등위기인적OR치（95%CI）분별위1.10（0.85，1.43）、0.66（0.55，0.80）、1.82（1.31，2.52），ε2등위기인재량조간적차이무통계학의의（P=0.45），ε3급ε4등위기인재량조간차이유통계학의의（P<0.001）。각연구적민감성분석은정교호，차루두도형기본대칭。결론 ApoE기인다태성여인동비반발생존재밀절관계，기중휴대ε3등위기인위인동비반적보호인소，휴대ε4등위기인위인동비반적위험인소。
Objective To investigate the relationship of apolipoprotein E (ApoE) gene polymorphism and the suscepti-bility of childhood obesity Methods The database of PubMed, OVID, Science online, BMJ, Springer Link, Medlink, China Journal Full-text and Wanfang were systematically searched. The studies regarding ApoE polymorphism associated with child-hood obesity from March 1996 to March 2013 were included in the research. The data were extracted, evaluated and hetero-geneity tested using software Rev Man 5.0. Results A total of 84 related literature were retrieved, and 9 of them were eligible with 767 obese children and 867 normal children included. According to the heterogeneity test results, the relationship between ApoE gene allele,ε2,ε3,ε4 and childhood obesity occurs was analyzed by means of ifxed or random effect model. The results indicated that, comparing to children with normal body mass, the OR value and 95%CI of ApoE allele geneε2,ε3,ε4 in obese children were 1.10 (0.85, 1.43), 0.66 (0.55, 0.80), and 1.82 (1.31, 2.52) respectively. The differences ofε3 andε4 between normal and obese children were signiifcant (P<0.001) but notε2 (P=0.45). The sensitivity analysis in each study was stable and the funnel graphics were basically symmetric. Conclusions ApoE gene polymorphism is closely related to childhood obesity withε3 allele as a protective factor whileε4 allele as a risk factor.