CAJ | 학술논문

目的：探讨足月新生儿缺氧缺血性脑病（HIE）患儿在新生儿期、出生后4个月和4岁时的脑部磁共振成像（MRI）表现及其与预后的关系。方法对24例HIE患儿进行定期MRI检查；分析和比较新生儿期、出生后4个月和4年的MRI检查结果，及患儿4岁时的神经功能。结果 HIE患儿新生儿期MRI常表现为脑室周围白质信号改变和深部灰质受累。新生儿期深部灰质受累患儿，常表现为神经功能不良，预后较差；复查MRI表现为脑软化和脑室周围白质软化患儿的预后也较差。出生后4个月和4年时的MRI检查预测HIE患儿神经功能的阳性预测值高。结论 HIE患儿出生4个月行MRI检查较为重要，可预测患儿今后神经功能结果，指导临床干预。
목적：탐토족월신생인결양결혈성뇌병（HIE）환인재신생인기、출생후4개월화4세시적뇌부자공진성상（MRI）표현급기여예후적관계。방법대24례HIE환인진행정기MRI검사；분석화비교신생인기、출생후4개월화4년적MRI검사결과，급환인4세시적신경공능。결과 HIE환인신생인기MRI상표현위뇌실주위백질신호개변화심부회질수루。신생인기심부회질수루환인，상표현위신경공능불량，예후교차；복사MRI표현위뇌연화화뇌실주위백질연화환인적예후야교차。출생후4개월화4년시적MRI검사예측HIE환인신경공능적양성예측치고。결론 HIE환인출생4개월행MRI검사교위중요，가예측환인금후신경공능결과，지도림상간예。
Objectives To explore the characteristics and value of magnetic resonance imaging (MRI) in predicting prognosis of hypoxic ischemic encephalopathy (HIE) in neonatal period, at 4 months and 4 years old. Methods Twenty-four patients with HIE were examined by MRI. Their MRI results in the neonatal period, at month 4 and year 4 and neurological functions at year 4 were compared. Results Periventricular signal alterations and deep gray matter involvement were common in HIE neonates. The neonates with deep gray matter involvement usually had neurological malfunction and poor prognosis. The patients with encephalomalacia and periventricular leukomalacia at 4 months and 4 years old also had poor prognosis. The abnormal MRI ifndings in HIE children at 4 month and 4 year old predicted the occurrence of neurological malfunction. Con-clusions The MRI of infant at 4 months old is important in prediction of neurological malfunction and provides guidance of clinical intervention for children with HIE.