CAJ | 학술논문

目的：探讨阿托伐他汀和辛伐他汀治疗老年冠心病合并高脂血症的临床效果。方法选择75例冠心病合并高脂血症患者，随机分为观察组和对照组。观察组给予阿托伐他汀治疗，对照组给予辛伐他汀治疗。观察两组患者治疗前和治疗后血脂及肝肾功能改变情况。结果观察组治疗后的三酰甘油、血总胆固醇、低密度脂蛋白胆固醇和高密度脂蛋白胆固醇水平分别与对照组治疗后比较，差异有统计学意义（P<0.05）。观察组和对照组患者治疗后谷丙转氨酶、尿素氮和肌酐分别与该组治疗前比较，差异无统计学意义（P>0.05）。结论阿托伐他汀治疗老年冠心病合并高脂血症临床效果显著，优于辛伐他汀。
목적：탐토아탁벌타정화신벌타정치료노년관심병합병고지혈증적림상효과。방법선택75례관심병합병고지혈증환자，수궤분위관찰조화대조조。관찰조급여아탁벌타정치료，대조조급여신벌타정치료。관찰량조환자치료전화치료후혈지급간신공능개변정황。결과관찰조치료후적삼선감유、혈총담고순、저밀도지단백담고순화고밀도지단백담고순수평분별여대조조치료후비교，차이유통계학의의（P<0.05）。관찰조화대조조환자치료후곡병전안매、뇨소담화기항분별여해조치료전비교，차이무통계학의의（P>0.05）。결론아탁벌타정치료노년관심병합병고지혈증림상효과현저，우우신벌타정。
Objective To explore the clinical effect of atorvastatin and simvastatin on elderly patients with coronary heart disease and hyperlipidemia. Methods 75 patients with coronary heart disease and hyperlipidemia patients, were selected and randomly di-vided into observation group and control group. The observation group was given atorvastatin, the control group was given simvas-tatin. The blood lipid and renal function changes were observede before and after treatment in two groups. Results The three tria-cylglycerol, serum total cholesterol, low density lipoprotein cholesterol and high density lipoprotein cholesterol levels in the obser-vation group after treatment compared with those in the control group after treatment,the difference was statistically significant (P<0.05);The alanine aminotransferase, blood urea nitrogen and serum creatinine in the observation group after treatment compared with those in the control group after treatment,the difference was no statistically significant (P>0.05). Conclusion atorvastatin on elderly patients with coronary heart disease and hyperlipidemia has significant clinical effect, and the clinical effect is better than simvastatin.