CAJ | 학술논문

产气荚膜梭菌（Clostridium per f ringens）是一种人兽共患病的病原体，能引起各种动物和人患气性坏疽，肠毒血症，羊和山羊羔羊痢疾等肠道疾病。该菌产生的毒素至少有16种之多，ι毒素是产气荚膜梭菌主要致死毒素中唯一的一种二元毒素，由一种ADP核糖基转移酶组件（Ia）和一种绑定组件（Ib）组成，可引起羔羊、犊牛和家兔患肠毒血症。近年来，ι毒素引发的患肠毒血症的动物有向多而广发展的趋势，所以有必要对产气荚膜梭菌做更加深入的研究。论文就ι毒素的分子结构和功能、致病机制以及检测和预防进行了阐述，以期对今后有关ι毒素的研究有所帮助。
산기협막사균（Clostridium per f ringens）시일충인수공환병적병원체，능인기각충동물화인환기성배저，장독혈증，양화산양고양이질등장도질병。해균산생적독소지소유16충지다，ι독소시산기협막사균주요치사독소중유일적일충이원독소，유일충ADP핵당기전이매조건（Ia）화일충방정조건（Ib）조성，가인기고양、독우화가토환장독혈증。근년래，ι독소인발적환장독혈증적동물유향다이엄발전적추세，소이유필요대산기협막사균주경가심입적연구。논문취ι독소적분자결구화공능、치병궤제이급검측화예방진행료천술，이기대금후유관ι독소적연구유소방조。
Clostridium per f ringens as an important zoonotic pathogens can cause diseases such as gas gan-grene ,enterotoxemia of sheep and goat and lamb dysentery ,and others .The bacteria can produce at least 16 toxins ,ιtoxin is the only binary toxin of all the toxins ,w hich is composed of an ADP ribose base trans-ferase (Ia) component and a binding component (Ib) ,and it can cause enterotoxemia of lamb ,calf ,and rabbit .In recent years ,more and more animals suffering from E type enterotoxemia ,so it is necessary to study deeply and comprehensively . This thesis elaborates research progress in structure and function , pathogenic mechanism ,and detection and prevention of Clostridium per f ringensιtoxin .It is helpful for the future research onιtoxin .