CAJ | 학술논문

奶牛子宫内膜炎是造成奶牛不孕的主要原因之一，严重影响奶牛业的发展。奶牛子宫内膜炎炎症发展过程中，多种因素对奶牛子宫的免疫调节均有不同程度的影响。奶牛子宫内的免疫防御机制主要是通过细胞免疫和体液免疫在起作用，其作用过程主要是通过子宫的特异性免疫和非特异性免疫在发挥作用。目前对奶牛子宫炎具有免疫调控作用的物质主要有细胞因子、激素、天然产物及抗原等，这些物质通过刺激奶牛机体的免疫应答，或者提高机体的免疫力而对奶牛子宫的炎症起到调理作用。论文从不同角度、不同层面对奶牛子宫内膜炎免疫机制及免疫调控进行了综述，对于奶牛子宫内膜炎进一步深入研究，研发预防和治疗该病的新型免疫制剂及疫苗提供参考。
내우자궁내막염시조성내우불잉적주요원인지일，엄중영향내우업적발전。내우자궁내막염염증발전과정중，다충인소대내우자궁적면역조절균유불동정도적영향。내우자궁내적면역방어궤제주요시통과세포면역화체액면역재기작용，기작용과정주요시통과자궁적특이성면역화비특이성면역재발휘작용。목전대내우자궁염구유면역조공작용적물질주요유세포인자、격소、천연산물급항원등，저사물질통과자격내우궤체적면역응답，혹자제고궤체적면역력이대내우자궁적염증기도조리작용。논문종불동각도、불동층면대내우자궁내막염면역궤제급면역조공진행료종술，대우내우자궁내막염진일보심입연구，연발예방화치료해병적신형면역제제급역묘제공삼고。
Cow endometritis is considered to be one of the important factors of infertility w hich blocked the development of dairy industry .The immunoregulation of uterus is affected by many factors at different de-gree during the course of endometritis development .The main immune defense mechanisms of uterus in cows include cell-mediated immunity and humoral immunity which work through specific immunity and non-specific immunity ,respectively .At the present ,it is reported that immunoregulation substances (cy-tokines ,hormone ,natural product and antigen et al ) could stimulate immune response or enhance immuni-ty of cow to regulate inflammation in cow uterus .This paper summarized immunologic mechanisms and immunoregulation involved cow endometritis ,which will be the foundation for further study of this disease and guideline of the new immune preparations and vaccines to prevent and cure cow endometritis .