CAJ | 학술논문

目的：探讨表现为小量蛋白尿IgA肾病患者临床表现及牛津病理分型特点。方法80例经肾穿刺活检诊断原发性IgA肾病患者根据其24 h尿蛋白定量结果分为尿蛋白≤500 mg/24 h；500～1000 mg/24 h；＞1000 mg/24 h三组，进行临床及病理资料回顾性分析。结果临床特点中尿蛋白量与高血压的发生具有相关性（P＜0．05）；临床指标中尿蛋白量与估算肾小球率过滤（eGFR）、血浆白蛋白、血红蛋白之间存在相关性（P＜0．05）；牛津病理分型中各指标与尿蛋白量之间差异无统计学意义。结论对于尿蛋白≤500 mg/24 h 原发性IgA肾病患者的评估尚须进一步明确，对500～1000 mg/24 h需加以重视、强调积极的肾活检及临床干预。
목적：탐토표현위소량단백뇨IgA신병환자림상표현급우진병리분형특점。방법80례경신천자활검진단원발성IgA신병환자근거기24 h뇨단백정량결과분위뇨단백≤500 mg/24 h；500～1000 mg/24 h；＞1000 mg/24 h삼조，진행림상급병리자료회고성분석。결과림상특점중뇨단백량여고혈압적발생구유상관성（P＜0．05）；림상지표중뇨단백량여고산신소구솔과려（eGFR）、혈장백단백、혈홍단백지간존재상관성（P＜0．05）；우진병리분형중각지표여뇨단백량지간차이무통계학의의。결론대우뇨단백≤500 mg/24 h 원발성IgA신병환자적평고상수진일보명학，대500～1000 mg/24 h수가이중시、강조적겁적신활검급림상간예。
Objective To analyse the clinical manifestations and Oxford pathological grading in IgA nephropathy patients with mini-mal proteinuria.Methods The clinical and pathological material of 80 cases of IgA nephropathy patients from this hospital was retrospective-ly analysed,and the patients were divided into 3 groups according to the 24 h urine protein quantitative results:proteinuria:≤500 mg/24 h, 500~1 000 mg/24 h,and>1 000 mg/24 h.Results The proteinuria was related with hypertension(P<0.05).As for the clinical indexes, there was difference among proteinuria with estimated glomerular filtration rate(eGFR),albumin and hemoglobin(P<0.05).As for the path-ological grading,there was no significant difference.Conclusion More studies are needed to evaluate IgA nephropathy with proteinuria≤500 mg/24 h;and clinicians should strengthen the monitoring of the related indicators of the patients with proteinuria 500~1 000 mg/24 h to con-trol the disease.