CAJ | 학술논문

目的：优选川芎凝胶膏剂的基质处方。方法采用均匀设计方法，以初黏力、持黏力、剥离强度、膜残留为评价指标，结合效应面法，筛选川芎凝胶膏剂基质中NP-700、甘羟铝、甘油、酒石酸的用量及药物浓缩程度和加入体积。结果凝胶膏剂最优配比组成为：NP-700∶甘羟铝∶甘油∶酒石酸∶药液浓度∶加入体积＝1.1∶0.08∶7∶0.04∶4∶5。结论均匀设计结合效应面法可用于凝胶膏剂的基质筛选，制得的贴膏载药量高，且具有良好的涂展性、保湿性，黏着力良好。
목적：우선천궁응효고제적기질처방。방법채용균균설계방법，이초점력、지점력、박리강도、막잔류위평개지표，결합효응면법，사선천궁응효고제기질중NP-700、감간려、감유、주석산적용량급약물농축정도화가입체적。결과응효고제최우배비조성위：NP-700∶감간려∶감유∶주석산∶약액농도∶가입체적＝1.1∶0.08∶7∶0.04∶4∶5。결론균균설계결합효응면법가용우응효고제적기질사선，제득적첩고재약량고，차구유량호적도전성、보습성，점착력량호。
Objective To optimize the matrix formulation of the extract of Chuanxiong Rhizoma cataplasm. Methods The optimal proportion of matrix formulation was selected by uniform design and response surface method. The primary adhesion force, lasting adhesion force, peel strength and residuals on the anti-sticking paper were used as test parameters. The optimal ratios of NP-700, glycinate aluminum, glycerin, tartaric acid, the concentration of drug, and the volume of drug were acquired. Results The matrix formulation of the cataplasm was made with NP-700∶glycinate aluminum∶glycerin∶tartaric acid∶concentration of drug∶volume of drug=1.1∶0.08∶7∶0.04∶4∶5. Conclusion Uniform design combined with response surface method can be used for the optimization of the matrix formulation of cataplasm. The optimal matrix prescription has higher drug-loading, with good spreadability, moisture-retention capability and adhesive force.