CAJ | 학술논문

目的：探索治疗围绝经期综合征中药复方的用药规律。方法检索公开发表的文献中治疗围绝经期综合征的中药复方，建立相应数据库，采用频数分析、聚类分析、关联规则等方法对复方进行数据挖掘，对主要药物、药对(组)规律进行探讨。结果在治疗围绝经期综合征的49首中药复方中共用药100种、553频次；以使用频次≥3的共57种、504频次，作为主要药物进行聚类分析，共分为滋补药、清热药、温补药、补气药、安神药、平肝药、疏肝药、益智药8类药物；经关联规则分析，共得药对规则39条，药组规则17条。结论应用数据挖掘方法探索治疗围绝经期综合征中药复方用药规律是可行的。
목적：탐색치료위절경기종합정중약복방적용약규률。방법검색공개발표적문헌중치료위절경기종합정적중약복방，건립상응수거고，채용빈수분석、취류분석、관련규칙등방법대복방진행수거알굴，대주요약물、약대(조)규률진행탐토。결과재치료위절경기종합정적49수중약복방중공용약100충、553빈차；이사용빈차≥3적공57충、504빈차，작위주요약물진행취류분석，공분위자보약、청열약、온보약、보기약、안신약、평간약、소간약、익지약8류약물；경관련규칙분석，공득약대규칙39조，약조규칙17조。결론응용수거알굴방법탐색치료위절경기종합정중약복방용약규률시가행적。
Objective To study the regularity of compound herbal formulae for perimenopausal syndrome. Methods Compound herbal formulae published on journals for the treatment of perimenopausal syndrome was searched and collected. A database was established for data mining using frequency count, cluster analysis and association rule analysis. Regularity of key herbs and pair (group) of herbs was summarized. Results There were 49 prescriptions (totaling 100 herbs and 553 counts of frequency) in the compound herbal formulae for perimenopausal syndrome. The herbs which were used for more than 3 times included 57 herbs (totally 504 counts of frequency), and they were cluster analysed and classified into 8 clusters including drugs for invigoration, clearing heat, warming and nourishing, restoring vital energy, tranquilizing, calming the liver, soothing the liver, and promoting mentality. The rules in pair of herbs were 39, and rules in group of herbs were 17, by using association rule analysis. Conclusion It was feasible that study the regularity of Chinese compound prescription for the treatment of perimenopausal syndrome by using data mining.