CAJ | 학술논문

目的：探讨胃肠道间质瘤的诊断及治疗。方法：回顾性分析2005年1月至2012年6月收治的38例胃肠道间质瘤患者的临床资料。结果：38例胃肠道间质瘤术前确诊1例。全组术后1、3、5年生存率分别为96．7％、87．2％、70．3％，完全切除组中位生存期为72个月。不完全切除组中位生存期仅21个月，完全切除组明显优于不完全切除组（P＜0．05）。完全切除组中，肿瘤局部切除和肿瘤所在器官切除患者生存率比较，差异无统计学意义（P＞0．05）。单因素分析显示：肿瘤的大小，核分裂数目，肿瘤是否完整切除，肿瘤坏死性破裂等因素间生存率比较有统计学意思（P＜0．05）。结论：胃肠道间质瘤术前确诊困难，完整的局部切除是最有效的治疗手段，广泛切除或扩大淋巴结清扫，不能提高生存率，高危患者术后口服伊马替尼可提高治疗效果。
목적：탐토위장도간질류적진단급치료。방법：회고성분석2005년1월지2012년6월수치적38례위장도간질류환자적림상자료。결과：38례위장도간질류술전학진1례。전조술후1、3、5년생존솔분별위96．7％、87．2％、70．3％，완전절제조중위생존기위72개월。불완전절제조중위생존기부21개월，완전절제조명현우우불완전절제조（P＜0．05）。완전절제조중，종류국부절제화종류소재기관절제환자생존솔비교，차이무통계학의의（P＞0．05）。단인소분석현시：종류적대소，핵분렬수목，종류시부완정절제，종류배사성파렬등인소간생존솔비교유통계학의사（P＜0．05）。결론：위장도간질류술전학진곤난，완정적국부절제시최유효적치료수단，엄범절제혹확대림파결청소，불능제고생존솔，고위환자술후구복이마체니가제고치료효과。
Objective :To investigate the diagonosis and treatment for gastrointestinal stromal tumors (GLST) .Methods :From January 2005 to june 2012 ,38 case with GLTS were analyzed retrospectivel .Results :Of the 38 cases ,1 case was preoperative diagnosis .The 1 - ,3 - ,5 -year surrival rate of the 38 cases after the operation was 96 .7% ,87 .2% ,7 .03% .Complet operation resection group ,the median survival period of 72 months .Incomplete resection group ,the median survival period of 21 months .The former group was signficantly better than the latter group (P< 0 .05) .In the complete opration resection ,to comparison of surrival rate in the local excison of the tumor and tumor organ resection patients ,the difference was not statisticall significant(P>0 .05) .Comparison of tumor size ,mitotic count ,complete resection ,tumor necrosis rupture were related with surrival rates on single fac-tor analysis(P<0 .05) .Conclusions :Diagnosis of GIST is difficult before operation .The most effective treatment is complete excision operation ,The surrival cannot be improved by extensive resection and lymph node clearance .Imatinib perhaps has the effect to prevent tummor recurrence for high risk patients .