大家健康（下旬版）
大傢健康（下旬版）
대가건강（하순판）
FOR ALL HEALTH
2013年
12期
12-12,13
,共2页
宫颈癌%放疗%化疗%同步放化疗
宮頸癌%放療%化療%同步放化療
궁경암%방료%화료%동보방화료
cervical cancer%radiotherapy%chemotherapy%concurrent chemoradiotherapy
目的：探讨同步放化疗相对于单纯放疗或单纯化疗的非手术疗法治疗中晚期宫颈癌的有效性。方法：收集2005-2012年本院妇科和放化疗科诊治的中晚期宫颈癌病人，从中选取符合治疗条件的病人分为三组：（1）单纯放疗组30例；（2）单纯化疗组20例；（3）放化疗联合治疗组80例。对这130例病人的临床资料进行对比分析。结果：单纯放疗组低分化者肿瘤缩小率（55．7％）显著高于高中分化者（35．4％），单纯化疗组高中分化者肿瘤缩小率（61．1％）显著高于低分化者（42．3％），同步放化疗组分化程度与肿瘤缩小率无统计学差异；同步放化疗组肿瘤平均缩小率（72．6％）显著高于单纯放疗组（37．7％）和单纯化疗组（44．6％）（P＜0．05）。宫旁转移率三者比较差异无统计学意义。结论：同步放化疗可使肿瘤体积在明显缩小，并能降低淋巴结转移率，延长生存期。低分化宫颈癌对放疗敏感，高中分化宫颈癌对化疗敏感。晚期浸润性宫颈癌治疗中同步放化疗较单纯放化疗更有效。
目的：探討同步放化療相對于單純放療或單純化療的非手術療法治療中晚期宮頸癌的有效性。方法：收集2005-2012年本院婦科和放化療科診治的中晚期宮頸癌病人，從中選取符閤治療條件的病人分為三組：（1）單純放療組30例；（2）單純化療組20例；（3）放化療聯閤治療組80例。對這130例病人的臨床資料進行對比分析。結果：單純放療組低分化者腫瘤縮小率（55．7％）顯著高于高中分化者（35．4％），單純化療組高中分化者腫瘤縮小率（61．1％）顯著高于低分化者（42．3％），同步放化療組分化程度與腫瘤縮小率無統計學差異；同步放化療組腫瘤平均縮小率（72．6％）顯著高于單純放療組（37．7％）和單純化療組（44．6％）（P＜0．05）。宮徬轉移率三者比較差異無統計學意義。結論：同步放化療可使腫瘤體積在明顯縮小，併能降低淋巴結轉移率，延長生存期。低分化宮頸癌對放療敏感，高中分化宮頸癌對化療敏感。晚期浸潤性宮頸癌治療中同步放化療較單純放化療更有效。
목적：탐토동보방화료상대우단순방료혹단순화료적비수술요법치료중만기궁경암적유효성。방법：수집2005-2012년본원부과화방화료과진치적중만기궁경암병인，종중선취부합치료조건적병인분위삼조：（1）단순방료조30례；（2）단순화료조20례；（3）방화료연합치료조80례。대저130례병인적림상자료진행대비분석。결과：단순방료조저분화자종류축소솔（55．7％）현저고우고중분화자（35．4％），단순화료조고중분화자종류축소솔（61．1％）현저고우저분화자（42．3％），동보방화료조분화정도여종류축소솔무통계학차이；동보방화료조종류평균축소솔（72．6％）현저고우단순방료조（37．7％）화단순화료조（44．6％）（P＜0．05）。궁방전이솔삼자비교차이무통계학의의。결론：동보방화료가사종류체적재명현축소，병능강저림파결전이솔，연장생존기。저분화궁경암대방료민감，고중분화궁경암대화료민감。만기침윤성궁경암치료중동보방화료교단순방화료경유효。
Objective :To compare the effects of three non -surgical therapies (radiotherapy ,chemotherapy ,concurrent chemoradiotherapy ) for local advanced cervical cancer .Methods:130 cases of cervical cancer were collected in our hospital between2005 to 2012 .Theywere divided into radiotherapy group (30 cases) ,chemotherapy group (20 cases) ,concurrentchemoradiotherapy group (80 cases) .The relationship between effects and clinical-datawere analyzed .Results :Themetastasis rate of lymph node was 50% ,inradiotherapy group and 40% in chemotherapy whichwere higher than that of concurrent chemoradiotherapy group(12 .5% );the curative effect of radiotherapy group was significantly better in poorly differentiated group and the effect of chemotherapy group was significantly better in well differentiated group .Thecurative effect of concurrent chemoradiotherapy group was sig-nificantly higher than that of radiotherapy group and chemotherapy group when the cases were in later stages (P<0 .05) .There was no difference of parametrial transformationrates in the three groups (P>0 .05) .Conclusion:Concurrent chemoradiotherapy before operations both can reduce the size of tumor ,improve the chance of operation ,make themetastasis rate of lymph node lower ;Poorly differentiated caseswere sensitive to radiotherapy , whilewelldifferentiated oneswere sensitive to chemotherapy ;Theshort - term effectof concurrent chemoradiotherapy in later stageswas significantly higher than thatof radiotherapy and chemotherapy .
