大家健康(下旬版)
大傢健康(下旬版)
대가건강(하순판)
FOR ALL HEALTH
2013年
12期
10-11
,共2页
非酒精性脂肪肝%肥胖%胰岛素抵抗%脂联素
非酒精性脂肪肝%肥胖%胰島素牴抗%脂聯素
비주정성지방간%비반%이도소저항%지련소
nonalcoholic fatty liver disease%obesity%insulin resistance%adiponectin
目的:研究肥胖或超重伴非酒精性脂肪肝(NAFLD)患者血清脂联素与胰岛素抵抗的关系。方法:川北医学院附属医院2012年1月~2012年12月住院及门诊患者,肥胖伴非酒精性脂肪肝患者30例(A 组),非酒精性脂肪肝患者30例(B组),正常对照者30例(C 组),检测丙氨酸氨基转移酶(ALT)、空腹血糖(FBG)、甘油三酯(TG)、胆固醇(TC)、空腹胰岛素(FINS)和血清脂联素(APN)等水平变化,并计算腰臀比(WHR)、体重指数(BMI)、胰岛素抵抗指数(HOMA -IR)。结果:与C组比较,A 组、B组的ALT 、TG、TC、WHR 、BMI、HOMA -IR水平升高,APN 水平下降,差异均有统计学意义(P<0.05);A组的 ALT 、TG、TC、WHR 、BMI、HOMA -IR水平均较B组明显升高(P<0.05);A 组的 APN 水平较B组明显下降,差异均有统计学意义(P<0.05);APN 与WHR 、BMI、HOMA -IR呈显著负相关(P<0.05)。结论:脂联素与非酒精性脂肪肝、肥胖相关,低脂联素血症是非酒精性脂肪肝的危险因素。
目的:研究肥胖或超重伴非酒精性脂肪肝(NAFLD)患者血清脂聯素與胰島素牴抗的關繫。方法:川北醫學院附屬醫院2012年1月~2012年12月住院及門診患者,肥胖伴非酒精性脂肪肝患者30例(A 組),非酒精性脂肪肝患者30例(B組),正常對照者30例(C 組),檢測丙氨痠氨基轉移酶(ALT)、空腹血糖(FBG)、甘油三酯(TG)、膽固醇(TC)、空腹胰島素(FINS)和血清脂聯素(APN)等水平變化,併計算腰臀比(WHR)、體重指數(BMI)、胰島素牴抗指數(HOMA -IR)。結果:與C組比較,A 組、B組的ALT 、TG、TC、WHR 、BMI、HOMA -IR水平升高,APN 水平下降,差異均有統計學意義(P<0.05);A組的 ALT 、TG、TC、WHR 、BMI、HOMA -IR水平均較B組明顯升高(P<0.05);A 組的 APN 水平較B組明顯下降,差異均有統計學意義(P<0.05);APN 與WHR 、BMI、HOMA -IR呈顯著負相關(P<0.05)。結論:脂聯素與非酒精性脂肪肝、肥胖相關,低脂聯素血癥是非酒精性脂肪肝的危險因素。
목적:연구비반혹초중반비주정성지방간(NAFLD)환자혈청지련소여이도소저항적관계。방법:천북의학원부속의원2012년1월~2012년12월주원급문진환자,비반반비주정성지방간환자30례(A 조),비주정성지방간환자30례(B조),정상대조자30례(C 조),검측병안산안기전이매(ALT)、공복혈당(FBG)、감유삼지(TG)、담고순(TC)、공복이도소(FINS)화혈청지련소(APN)등수평변화,병계산요둔비(WHR)、체중지수(BMI)、이도소저항지수(HOMA -IR)。결과:여C조비교,A 조、B조적ALT 、TG、TC、WHR 、BMI、HOMA -IR수평승고,APN 수평하강,차이균유통계학의의(P<0.05);A조적 ALT 、TG、TC、WHR 、BMI、HOMA -IR수평균교B조명현승고(P<0.05);A 조적 APN 수평교B조명현하강,차이균유통계학의의(P<0.05);APN 여WHR 、BMI、HOMA -IR정현저부상관(P<0.05)。결론:지련소여비주정성지방간、비반상관,저지련소혈증시비주정성지방간적위험인소。
Objective :To study the obese or overweight patients with nonalcoholic fatty liver disease (NAFLD) with the relationship between serum adiponectin and insulin resistance .Methods:Inpatient and outpatient patients in Affilialiated Hospital of North Sichuan Medical College from January 2012 to December 2012 were selected .And obese patients with nonalcoholic fatty liver disease with 30 cases (group A) ,30 patients with nonalcoholic fatty liver disease (B group) ,30 cases of normal controls (group C) were selected .Such as ALT ,FBG ,TG ,TC ,FINS and APN were detected . WHR ,BMI ,HOMA -IR was calculated .Results:ALT ,TG ,TC ,WHR ,BMI ,HOMA -IR levels were obviously higher in the group A and group B than in the group group C ,but APN levels were obviously lower ,the differences were statistically significant (P<0 .05);ALT ,TG ,TC ,WHR , BMI ,HOMA -IR levels were obviously higher in A group than in the group B group (P<0 .05);APN levels were obviously lower in A group than in the group B ,the difference had statistical significance (P<0 .05);APN has significant negative correlation with WHR ,BMI ,HOMA -IR (P<0.05) .Conclusion:Adiponectin is associated with nonalcoholic fatty liver disease ,obesity ,low adiponectin levels are a risk factor for alcoholic fatty liver .