CAJ | 학술논문

目的：研究双相障碍不同亚型伴有焦虑障碍与不伴焦虑障碍患者临床表现、心理社会功能损害及治疗效果的差异。方法本研究将95例双相障碍患者根据其自身发病特点分成双相I型不伴有焦虑障碍组（28例），双相I型伴有焦虑障碍组（26例），双相Ⅱ型不伴有焦虑障碍组（20例），双相Ⅱ型伴有焦虑障碍组（21例）。同时将健康体检者作为对照组（30例），各组均实施韦氏记忆测验、注意测验及执行功能等神经心理学测验。结果双相I型伴有焦虑障碍组仅在工作记忆方面较不伴焦虑障碍组差，两组在注意及执行功能方面均低于对照组，但两者间的差异无统计学意义；双相Ⅱ型伴有焦虑障碍组在视觉即刻记忆、视觉延迟回忆、工作记忆和精神运动速度方面较不伴焦虑障碍组差。结论双相Ⅱ型伴焦虑障碍的患者在神经心理功能损害方面较双相I型伴有焦虑障碍患者更加严重。
목적：연구쌍상장애불동아형반유초필장애여불반초필장애환자림상표현、심리사회공능손해급치료효과적차이。방법본연구장95례쌍상장애환자근거기자신발병특점분성쌍상I형불반유초필장애조（28례），쌍상I형반유초필장애조（26례），쌍상Ⅱ형불반유초필장애조（20례），쌍상Ⅱ형반유초필장애조（21례）。동시장건강체검자작위대조조（30례），각조균실시위씨기억측험、주의측험급집행공능등신경심이학측험。결과쌍상I형반유초필장애조부재공작기억방면교불반초필장애조차，량조재주의급집행공능방면균저우대조조，단량자간적차이무통계학의의；쌍상Ⅱ형반유초필장애조재시각즉각기억、시각연지회억、공작기억화정신운동속도방면교불반초필장애조차。결론쌍상Ⅱ형반초필장애적환자재신경심리공능손해방면교쌍상I형반유초필장애환자경가엄중。
Objective To investigate the differences of clinical features between subtypes of bipolar disorder (BP) with or without co- morbid anxiety disorders (ADs). Methods Ninety- five BP patients were classified into 4 groups: BP- I without AD (n=28), BP- I with AD(n=26), BP- II without AD(n=20) and BP- II with AD(n=21);and 30 healthy subjects(HC) served as controls. Neuropsychological tests were performed in al patients and controls. Results The neuropsychological score of BP- I with AD patients was lower than that of BP- I without patients only in working memory. The neuropsychological scores in visual immediate memory, visual delayed memory, working memory, and psychomotor speed of BP- II with AD patients were significantly lower than those of BP- II without AD patients. Conclusion Our investigation indicates that co- morbid AD would damage the neu-ropsychological performance in BP- II patients more severely than those in BP- I patients.