CAJ | 학술논문

目的：探讨血清可溶性人类白细胞抗原- G（sHLA- G）水平及绒毛中血红素氧合酶-1（HO-1）蛋白的表达与早期流产的相关性。方法选择非自愿正常早期妊娠的患者60例作为对照组，自然流产患者80例，分为先兆流产组40例，稽留流产组40例，分别用ELISA法和免疫组化二步法分别检测血清sHLA- G水平和绒毛中HO-1蛋白的表达。结果相应的sHLA- G水平和HO-1蛋白表达由高到低依次排序为对照组、先兆流产组、稽留流产组，差异均有统计学意义（P＜0.05或0.01）。结论血清sHLA- G水平和绒毛中HO-1蛋白的表达与早期流产的发生、发展密切相关。
목적：탐토혈청가용성인류백세포항원- G（sHLA- G）수평급융모중혈홍소양합매-1（HO-1）단백적표체여조기유산적상관성。방법선택비자원정상조기임신적환자60례작위대조조，자연유산환자80례，분위선조유산조40례，계류유산조40례，분별용ELISA법화면역조화이보법분별검측혈청sHLA- G수평화융모중HO-1단백적표체。결과상응적sHLA- G수평화HO-1단백표체유고도저의차배서위대조조、선조유산조、계류유산조，차이균유통계학의의（P＜0.05혹0.01）。결론혈청sHLA- G수평화융모중HO-1단백적표체여조기유산적발생、발전밀절상관。
Objective To investigate the correlation of serum levels of soluble human leukocyte antigen(sHLA- G) and ex-pression of heme oxygenase- 1 (HO- 1) protein in vil i with early spontaneous abortion. Methods Eighty cases of early sponta-neous abortion, including 40 cases of threatened abortion and 40 cases of missed abortion, and 60 cases of unvoluntary normal pregnancy (control) were enrol ed in the study. The serum levels of sHLA- G and expression of HO- 1 in vil i were detected by ELISA and two- step immunohistochemical staining, respectively. Results The serum sHLA- G levels and HO- 1 protein expres-sion in vil i in control group were highest, fol owed by those in threatened abortion group, and those in missed abortion group were the lowest (P<0.05 or P<0.01). Conclusion Serum sHLA- G levels and HO- 1 protein expression in the vil i are associated with the development and progression of early spontaneous abortion.