CAJ | 학술논문

目的：观察手足口患儿免疫功能改变及其黄芪注射液及干扰素的免疫调节作用。方法收集手足口神经系统受累期患儿58例，随机分为对照组28例，黄芪联合干扰素治疗组30例，两组均给予基础治疗，联合治疗组加用黄芪注射液及重组人干扰素α-2b注射液，观察患儿一般情况改变并检测治疗过程中患儿细胞及体液免疫功能变化，评价黄芪注射液及干扰素的联合治疗作用。结果黄芪联合干扰素治疗组神经系统症状缓解时间、热程及疗程均较对照组短，差异有统计学意义（P＜0.05）；治疗3d时，对照组CD3、CD4、IgM较治疗前差异有统计学意义(P＜0.05)。与治疗前及对照组比较，黄芪联合干扰素治疗组免疫指标差异均有统计学意义(P＜0.05)。结论黄芪注射液联合干扰素可有效治疗手足口病，机制与免疫调节相关。
목적：관찰수족구환인면역공능개변급기황기주사액급간우소적면역조절작용。방법수집수족구신경계통수루기환인58례，수궤분위대조조28례，황기연합간우소치료조30례，량조균급여기출치료，연합치료조가용황기주사액급중조인간우소α-2b주사액，관찰환인일반정황개변병검측치료과정중환인세포급체액면역공능변화，평개황기주사액급간우소적연합치료작용。결과황기연합간우소치료조신경계통증상완해시간、열정급료정균교대조조단，차이유통계학의의（P＜0.05）；치료3d시，대조조CD3、CD4、IgM교치료전차이유통계학의의(P＜0.05)。여치료전급대조조비교，황기연합간우소치료조면역지표차이균유통계학의의(P＜0.05)。결론황기주사액연합간우소가유효치료수족구병，궤제여면역조절상관。
Objective To observe the immune function changes of HFMD and immunomodulatory ef ects of Astragalus injection combined with interferon. Methods fifty-eight cases of HFMD children in nervous system involvement stage were divided into 2 groups (28 cases in control group and 30 cases in Astragalus combined with interferon treatment group).Two groups were given basic treatment, and the treatment group were treated with Astragalus injection and interferon alfa-2b injection.To observer the general conditions and changes of cellular and humoral immune function in children,and evaluate the therapeutic ef ect of Astragalus injection and interferon. Results The dif erence was statistical y significant between the two groups in nervous system symptoms releif time and the process of heat and treatment (P< 0.05); at the 3 day of treatment, the CD3, CD4, IgM in control group had significant dif erence compared with those before treatment (P<0.05). Compared with control group and before treatment,al index of immune function in treatment group had significant dif erence (P< 0.05,). Conclusion Astragalus injection combined with interferon is ef ective in the treatment of hand foot and mouth disease.The mechanism. associated with immune regulation.