CAJ | 학술논문

目的探讨血浆视黄醇结合蛋白-4(RPB4)与动脉粥样硬化(AS)的关系。方法90例研究对象行颈动脉超声测量颈动脉内膜中层厚度(IMT)，根据IMT<1.0mm与≥1.0mm分为IMT正常组和IMT增厚组，测定血浆RPB4水平。结果 IMT增厚组的总胆固醇( TC)、低密度脂蛋白胆固醇( LDL-C)、糖化血红蛋白(HbA1c)、空腹胰岛素(FINS)、胰岛素抵抗指数(HOMA-IR)、高敏C反应蛋白(hsCRP)、RBP4及冠心病、2型糖尿病、脑动脉硬化患病率均显著高于IMT正常组，差异有显著性。相关分析显示血浆RBP4与腰围、体重指数、甘油三酯、TC、LDL-C、HbA1c、HOMA-IR、hsCRP、IMT呈正相关。结论血浆RBP4在AS的发生、发展过程中起到一定作用。
목적탐토혈장시황순결합단백-4(RPB4)여동맥죽양경화(AS)적관계。방법90례연구대상행경동맥초성측량경동맥내막중층후도(IMT)，근거IMT<1.0mm여≥1.0mm분위IMT정상조화IMT증후조，측정혈장RPB4수평。결과 IMT증후조적총담고순( TC)、저밀도지단백담고순( LDL-C)、당화혈홍단백(HbA1c)、공복이도소(FINS)、이도소저항지수(HOMA-IR)、고민C반응단백(hsCRP)、RBP4급관심병、2형당뇨병、뇌동맥경화환병솔균현저고우IMT정상조，차이유현저성。상관분석현시혈장RBP4여요위、체중지수、감유삼지、TC、LDL-C、HbA1c、HOMA-IR、hsCRP、IMT정정상관。결론혈장RBP4재AS적발생、발전과정중기도일정작용。
Objective To investigate the correlation between plasmal retinol-binding protein 4 ( RBP4 ) levels and atherosclerosis (AS). Method According to carotid intima-media thickness(IMT), 90 subjects were divided into two groups:the normal IMT group and the thickened IMT group. Plasmal RBP4 levels were measured by ELISA. Result Plasmal TC, LDL, HbA1c, FINS, HOMA-IR, hsCRP, RBP4 levels and the morbidity rate of coronary heart disease, type 2 diabetes mellitus and cerebral arteriosclerosis in the thickened IMT group was significantly higher than those in the normal IMT group, Plasmal RBP4 level was positively correlated with Waist, BMI, TC, TG, LDL, HbA1c, HOMA-IR, hsCRP, IMT. Conclusion Elevated RBP4 levels might affect the delevopment of AS.