CAJ | 학술논문

目的：探讨复方樟柳碱(compound anisondine,CA)治疗缺血性视神经病变(ischemic optic neuropathy)的疗效及安全性。方法缺血性视神经病变患者105例123只眼，随机分为常规治疗组和CA治疗组，均给予常规治疗，CA治疗组加用CA，疗程42d。治疗后随访3～8m。比较两组患者治疗后视力、视野、光学相干断层扫描（opticalcoherence tomography，OCT）测量视网膜神经纤维层厚度（retinalnervefiberlayer,RNFL）变化，并观察CA治疗的安全性。结果常规治疗和 CA治疗的总有效率分别为67.21%和95.16%，后者总有效率高于前者（P<0.05）。结论复方樟柳碱治疗缺血性视神经病变安全、有效，值得临床推广应用。
목적：탐토복방장류감(compound anisondine,CA)치료결혈성시신경병변(ischemic optic neuropathy)적료효급안전성。방법결혈성시신경병변환자105례123지안，수궤분위상규치료조화CA치료조，균급여상규치료，CA치료조가용CA，료정42d。치료후수방3～8m。비교량조환자치료후시력、시야、광학상간단층소묘（opticalcoherence tomography，OCT）측량시망막신경섬유층후도（retinalnervefiberlayer,RNFL）변화，병관찰CA치료적안전성。결과상규치료화 CA치료적총유효솔분별위67.21%화95.16%，후자총유효솔고우전자（P<0.05）。결론복방장류감치료결혈성시신경병변안전、유효，치득림상추엄응용。
Objective To investigate the ef icacy and safety of the compound anisondine (CA)in treating ischemic optic neuropathy. Methods Al 105 cases ( 123eyes) with ischemic optic neuropathy were randomly divided into normal treatment group and CA treatment group.Patients in normal treatment group were treated by conventional way and those in CA treatment group were treated with CA plus conventional treatment for 42 days. Three months later,the vision , Visual field changes and OCT dif erent groups were inspected and the safety was evaluated. Results The ef ective rate was 67.21% in normal treatment group and 95.16% in CA treatment group (P<0.05) in photocoagulation group. The general ef ective rate of later was higher than the former(P<0.05). Conclusions Compound anisondine is an ef ective and safe way to treat ischemic optic neuropathy,which is worth widely applying in clinical practice.