CAJ | 학술논문

目的：观察汉族与维吾尔族健康人群之间血清蛋白表达谱的变化。方法对30名维吾尔族及50名汉族健康体检者血清，采用弱阳离子交换蛋白芯片（C M 10）和表面增强激光解吸离子化飞行时间质谱技术检测蛋白谱。结果汉族和维吾尔族间血清蛋白质谱存在明显差异，其中汉族组中质荷比为1280、2747的2个蛋白质丰度显著高于维吾尔族组（ P ＜0.05）。结论维吾尔族与汉族健康人群之间的血清蛋白质指纹图谱有较明显差异，对建立新疆地区血清蛋白质指纹图谱疾病诊断模型具有参考价值。
목적：관찰한족여유오이족건강인군지간혈청단백표체보적변화。방법대30명유오이족급50명한족건강체검자혈청，채용약양리자교환단백심편（C M 10）화표면증강격광해흡리자화비행시간질보기술검측단백보。결과한족화유오이족간혈청단백질보존재명현차이，기중한족조중질하비위1280、2747적2개단백질봉도현저고우유오이족조（ P ＜0.05）。결론유오이족여한족건강인군지간적혈청단백질지문도보유교명현차이，대건립신강지구혈청단백질지문도보질병진단모형구유삼고개치。
Objective To compare serum protein profiles in Han nationality and Uygur nationality healthy persons .Methods Serum samples from healthy persons (50 Han and 30 Uygur subjects) were detected by weak cation exchange (CM10) protein chip assay using surface-enhanced laser desorption/ionization time-of-flight mass spectrometry(SELDI-TOF-MS) technology .Results Two peaks bearing mass to charge ratios of 1 280 and 2 747 were significantly higher in Han while lower in Uygur healthy persons ( P <0 .05) .Conclusion Han and Uygur healthy persons in Xinjiang exhibited different fingerprints of serum proteins ,such a difference will be significant to build a diagnostic model of diseases based on serum proteomics in Xinjiang .