河北医药
河北醫藥
하북의약
HEBEI MEDICAL JOURNAL
2013年
22期
3372-3374
,共3页
宫颈肿瘤%NF-κB%MMP-9%介入化疗
宮頸腫瘤%NF-κB%MMP-9%介入化療
궁경종류%NF-κB%MMP-9%개입화료
cervical carcinoma%NF-κB%MMP-9%interventional chemotherapy
目的：观察宫颈癌介入化疗前后组织中核转录因子-κB （ nuclear factor kappa-B，NF-κB）和MMP-9（matrix metalloproteinase，MMP-9）的表达及临床意义。方法采用免疫组织化学SP法检测80例宫颈癌（CSES）行动脉介入化疗前后、70例子宫颈上皮内瘤样变（CIN）及50例正常子宫颈组织（NCE）NF-κB和MMP-9的表达，分析其与临床病理特征的关系，探讨二者在介入化疗前后的表达情况及与介入化疗效果的关系。结果在CSES、CIN及NCE中，NF-κB、MMP-9蛋白阳性表达率分别为72哌．5％、18．6％、0％和68．8％、15．7％、0％，差异具有统计学意义（ P ＜0．05）。 NF-κB、MMP-9表达与宫颈癌不同的病理分级、临床分期和淋巴结转移状况有关（ P ＜0．05），与患者年龄和组织学类型无关，且二者表达呈明显正相关（ r＝0．872， P ＜0．05）。介入化疗总有效率为81．3％，且与治疗前比较NF-κB、MMP-9蛋白表达均显著降低。结论宫颈癌患者存在NF-κB和MMP-9的过表达，介入化疗后二者表达显著降低。介入化疗可通过抑制肿瘤细胞增殖、浸润和转移发挥治疗宫颈癌的作用。
目的：觀察宮頸癌介入化療前後組織中覈轉錄因子-κB （ nuclear factor kappa-B，NF-κB）和MMP-9（matrix metalloproteinase，MMP-9）的錶達及臨床意義。方法採用免疫組織化學SP法檢測80例宮頸癌（CSES）行動脈介入化療前後、70例子宮頸上皮內瘤樣變（CIN）及50例正常子宮頸組織（NCE）NF-κB和MMP-9的錶達，分析其與臨床病理特徵的關繫，探討二者在介入化療前後的錶達情況及與介入化療效果的關繫。結果在CSES、CIN及NCE中，NF-κB、MMP-9蛋白暘性錶達率分彆為72哌．5％、18．6％、0％和68．8％、15．7％、0％，差異具有統計學意義（ P ＜0．05）。 NF-κB、MMP-9錶達與宮頸癌不同的病理分級、臨床分期和淋巴結轉移狀況有關（ P ＜0．05），與患者年齡和組織學類型無關，且二者錶達呈明顯正相關（ r＝0．872， P ＜0．05）。介入化療總有效率為81．3％，且與治療前比較NF-κB、MMP-9蛋白錶達均顯著降低。結論宮頸癌患者存在NF-κB和MMP-9的過錶達，介入化療後二者錶達顯著降低。介入化療可通過抑製腫瘤細胞增殖、浸潤和轉移髮揮治療宮頸癌的作用。
목적：관찰궁경암개입화료전후조직중핵전록인자-κB （ nuclear factor kappa-B，NF-κB）화MMP-9（matrix metalloproteinase，MMP-9）적표체급림상의의。방법채용면역조직화학SP법검측80례궁경암（CSES）행동맥개입화료전후、70례자궁경상피내류양변（CIN）급50례정상자궁경조직（NCE）NF-κB화MMP-9적표체，분석기여림상병리특정적관계，탐토이자재개입화료전후적표체정황급여개입화료효과적관계。결과재CSES、CIN급NCE중，NF-κB、MMP-9단백양성표체솔분별위72고．5％、18．6％、0％화68．8％、15．7％、0％，차이구유통계학의의（ P ＜0．05）。 NF-κB、MMP-9표체여궁경암불동적병리분급、림상분기화림파결전이상황유관（ P ＜0．05），여환자년령화조직학류형무관，차이자표체정명현정상관（ r＝0．872， P ＜0．05）。개입화료총유효솔위81．3％，차여치료전비교NF-κB、MMP-9단백표체균현저강저。결론궁경암환자존재NF-κB화MMP-9적과표체，개입화료후이자표체현저강저。개입화료가통과억제종류세포증식、침윤화전이발휘치료궁경암적작용。
Objective To investigate the expression and significance of NF-κB and MMP-9 in cervical carcinoma tissues before and after interventional chemotherapy ( IC).Methods The expression levels of NF-κB and MMP-9 were detected by immunohistochemistry method in 80 cases of cervical carcinoma ( CSES) before and after IC,70 cases of cervical intraepithelial neoplasm (CIN) and 50 cases of normal cervical tissues (NCE).The therapeutic effect of IC and the correlation between the expressions and clinical pathological characteristics before and after IC were observed and analyzed .Results Among CSES,CIN and NCE tissues,the positive expression rates of NF-κB and MMP-9 proteins were 72.5%,18.6%,0 and 68.8%,15.7%,0,respectively.The expression levels of NF-κB and MMP-9 in CSES were significantly higher than those in CIN and NCE ( P <0.05).The expression levels of NF-κB and MMP-9 were correlated to the degree of cell differentiation ,clinical stage and lymph node metastasis of cervical carcinoma ,however,which were not related with patient ’s age and histological type.The expression levels of NF-κB were positively correlated with those of MMP-9 ( r =0.872, P <0.05).The total effective rate of IC was 81.3%,moreover,the expression levels of NF-κB and MMP-9 after IC were significantly decreased ,as compared with those before IC .Conclusion The overexpression of NF-κB and MMP-9 exists in patients with cervical carcinoma and IC can significantly reduce the expression levels of NF-κB and MMP-9,as a result,which may inhibit the proliferation ,infiltration,invasion and metastasis of tumor cells .
