CAJ | 학술논문

目的：探讨依据Pfirrmann分级的椎间盘髓核磁共振扩散张量成像相对T2值、ADC值、FA值的改变。方法对72例患者和30名健康志愿者均行腰椎常规MRI和轴位DTI序列检查。将正常与退变椎间盘分为1～5级，统计分析椎间盘髓核的相对T2值、ADC值和FA值关系。结果1、4、5级椎间盘相对T2值与ADC值呈正相关（ r值分别为0{．4563、0．6024和0．8601， P ＜0．05），与FA值呈负相关（ r值分别为-0．3851、-0．5356和-0．8287， P ＜0．05）。2级椎间盘，相对 T2值与 ADC 值正相关（ r ＝0．4941， P ＜0．01），相对T2值与FA值无相关性（ r ＝-0．2998， P ＞0．05）。3级椎间盘相对T2值与ADC值、相对T2值与FA值无相关性（ r值分别为0．2945、-0．0954， P ＞0．05）。 Pfirrmann分级分别与相对T2值、FA值、ADC值有相关性（ P ＜0．01）。1级椎间盘与其余各级椎间盘的相对T2值、FA值、ADC值差异均有统计学意义（ P ＜0．05）。结论 DTI可以作为判断椎间盘功能状况的有用指标。退变程度轻-中度的椎间盘可能经过治疗逆转退变过程。
목적：탐토의거Pfirrmann분급적추간반수핵자공진확산장량성상상대T2치、ADC치、FA치적개변。방법대72례환자화30명건강지원자균행요추상규MRI화축위DTI서렬검사。장정상여퇴변추간반분위1～5급，통계분석추간반수핵적상대T2치、ADC치화FA치관계。결과1、4、5급추간반상대T2치여ADC치정정상관（ r치분별위0{．4563、0．6024화0．8601， P ＜0．05），여FA치정부상관（ r치분별위-0．3851、-0．5356화-0．8287， P ＜0．05）。2급추간반，상대 T2치여 ADC 치정상관（ r ＝0．4941， P ＜0．01），상대T2치여FA치무상관성（ r ＝-0．2998， P ＞0．05）。3급추간반상대T2치여ADC치、상대T2치여FA치무상관성（ r치분별위0．2945、-0．0954， P ＞0．05）。 Pfirrmann분급분별여상대T2치、FA치、ADC치유상관성（ P ＜0．01）。1급추간반여기여각급추간반적상대T2치、FA치、ADC치차이균유통계학의의（ P ＜0．05）。결론 DTI가이작위판단추간반공능상황적유용지표。퇴변정도경-중도적추간반가능경과치료역전퇴변과정。
Objective To quantitatively analyze the changes of magnetic resonance diffusion tensor imaging parameters of degenerated intervertebral disks according to Pfirrmann grading .Methods 72 patients and 30 healthy volunteers were examined by 3.0T MRI for T1,T2 and DTI scan.According to T2WI of disks,the normal and degenerated intervertebral disks were divided into five groups ,and the correlation among relative T2 values,ADC values and FA values in the five groups was analyzed .Results The relative T2 values in 1,4 and 5 grade intervertebral disk were positively correlated with those of ADC ( P <0.05),however,which were negatively related to those of FA (P <0.05).The relative T2 values in grade 2 intervertebral disk were positively correlated to those of ADC ( r =0.4941, P <0.01),however,which were not related with those of FA ( r =-0.2998, P>0.05).The relative T2 values in grade 3 intervertebral disk were not correlated with those of ADC ,FA ( P >0.05).However the parameters value according to Pfirrmann grading was related to that of relative T 2,FA,ADC (P <0.01).There were significant differences in relative T 2 values,FA,ADC between grade 1 intervertebral disk and the other grade intervertebral disks ( P <0 .05 ) .Conclusion DTI can be regarded as a useful indicator to evaluate intervertebral disk function .The degeneration process of slight and moderate degree degenerated disks may be reversed through treatment .