CAJ | 학술논문

以自制的琥珀酰化壳聚糖(SUCS)和羟甲基-5-氟尿嘧啶(5-FuOH)为原料,制备了壳聚糖偶联载药体(SUCS-5-FuOH)。傅里叶红外光谱(FT-IR)、核磁共振(1 H-NMR )、热重(TG )和 X 粉末衍射(XRD)等技术表征了产物的化学结构、热稳定性和结晶行为。并通过紫外光谱(UV )分析了产物对5-FuOH 的接枝率及其体外释药行为。结果表明,SUCS和5-FuOH 间通过酯键化学键合,接枝率(载药率)为18.7%,在模拟体液和酶存在条件下均有良好的缓释性能。
이자제적호박선화각취당(SUCS)화간갑기-5-불뇨밀정(5-FuOH)위원료,제비료각취당우련재약체(SUCS-5-FuOH)。부리협홍외광보(FT-IR)、핵자공진(1 H-NMR )、열중(TG )화 X 분말연사(XRD)등기술표정료산물적화학결구、열은정성화결정행위。병통과자외광보(UV )분석료산물대5-FuOH 적접지솔급기체외석약행위。결과표명,SUCS화5-FuOH 간통과지건화학건합,접지솔(재약솔)위18.7%,재모의체액화매존재조건하균유량호적완석성능。
Chitosan coupling drug-loading body (SUCS-5-FuOH)was prepared with homemade succinyl-chi-tosan (SUCS)and hydroxymethyl-5-fluorouracil (5-FuOH)as materials.The chemical structure,thermal sta-bility and crystallization behavior of the obtained sample were characterized by Fourier infrared spectrum (FT-IR),nuclear magnetic resonance (1 H-NMR),thermal gravimetric analysis (TG)and X-ray powder diffraction (XRD).The grafting rate of 5-FuOH and the in vitro releasing performance were analysed by UV spectrum (UV).The results indicated that SUCS and 5-FuOH were chemically bonded through ester linkage,the graft-ing rate (drug loading rate)of SUCS-5-FuOH was 18.7%,and it had good sustained-release performance under the condition of simulated body fluids and enzymes.