CAJ | 학술논문

目的：探讨阿托伐他汀在高血压性早期肾损害治疗中的疗效及其作用机制。方法：将本院收治的79例高血压伴早期肾损害患者按照分层随机分组法分为观察组和对照组，对照组给予抗高血压常规治疗，观察组在此基础上给予阿托伐他汀，观察两组的血脂水平、血压及肾早期损害指标改善情况。结果：观察组SBP （112.7±7.4）mm Hg、DBP （71.2±3.5）mm Hg，对照组SBP （126.5±8.3）mm Hg、DBP （76.9±2.7） mm Hg，两组比较差异有统计学意义（P<0.05）；观察组血脂水平、肾功能早期损伤指标均显著优于对照组，比较差异有统计学意义（P<0.05）。结论：阿托伐他汀具有较好的肾脏保护作用，能显著提高高血压伴早期肾损害的临床疗效。
목적：탐토아탁벌타정재고혈압성조기신손해치료중적료효급기작용궤제。방법：장본원수치적79례고혈압반조기신손해환자안조분층수궤분조법분위관찰조화대조조，대조조급여항고혈압상규치료，관찰조재차기출상급여아탁벌타정，관찰량조적혈지수평、혈압급신조기손해지표개선정황。결과：관찰조SBP （112.7±7.4）mm Hg、DBP （71.2±3.5）mm Hg，대조조SBP （126.5±8.3）mm Hg、DBP （76.9±2.7） mm Hg，량조비교차이유통계학의의（P<0.05）；관찰조혈지수평、신공능조기손상지표균현저우우대조조，비교차이유통계학의의（P<0.05）。결론：아탁벌타정구유교호적신장보호작용，능현저제고고혈압반조기신손해적림상료효。
Objective: To explore the clinical efficacy and mechanism of atorvastatin in the treatment of hypertensive patients with early renal injury.Method:According to a stratified randomization method, 79 hypertension patients with early renal damage were divided into observation group and control group in our hospital, the control group was given conventional anti-hypertensive drugs, and the observation group was given atorvastatin on the basis of the control group, then lipid levels, blood pressure, and renal injury indicators of the two groups were observed.Result: SBP of the observation group was (112.7±7.4)mm Hg, DBP was (71.2±3.5)mm Hg, and SBP of the control group was (126.5±8.3)mm Hg, DBP was (76.9±2.7)mm Hg, the difference between the two groups was significant (P<0.05). Lipid levels and renal injury indicators of the observation group were significantly better than those of the control group, the difference between the two groups was significant (P<0.05).Conclusion: Atorvastatin has significant renal protective effect, it can reduce renal damage and improve renal function in hypertension patients.