CAJ | 학술논문

目的：探讨脑梗死患者血清骨保护素（OPG）与颈动脉粥样硬化斑块的关系。方法将96例脑梗死患者根据颈动脉血管彩色多普勒超声检查评估有无粥样硬化斑块分为2组：颈动脉粥样硬化斑块组（64例）和颈动脉无粥样硬化斑块组（32例），颈动脉粥样硬化斑块组再根据粥样硬化斑块性质分为2亚组：颈动脉粥样硬化稳定斑块组（30例）和颈动脉粥样硬化不稳定斑块组（34例）。采用全自动生化仪检测血清C-反应蛋白（CRP）、低密度脂蛋白胆固醇（LDL-C）和同型半胱氨酸（Hcy）水平，采用酶联免疫法（ELISA法）检测血清OPG水平，并与31例健康对照组进行比较。结果颈动脉无粥样硬化斑块组、颈动脉粥样硬化稳定斑块组和颈动脉粥样硬化不稳定斑块组血清CRP、Hcy和OPG水平均明显高于健康对照组（均P＜0.05），颈动脉粥样硬化稳定斑块组血清OPG水平明显高于颈动脉无粥样硬化斑块组（P＜0.05），颈动脉粥样硬化不稳定斑块组血清OPG水平明显高于颈动脉粥样硬化稳定斑块组、颈动脉无粥样硬化斑块组（P＜0.05）。结论脑梗死患者血清OPG水平显著升高，并与颈动脉粥样硬化斑块稳定性密切相关。
목적：탐토뇌경사환자혈청골보호소（OPG）여경동맥죽양경화반괴적관계。방법장96례뇌경사환자근거경동맥혈관채색다보륵초성검사평고유무죽양경화반괴분위2조：경동맥죽양경화반괴조（64례）화경동맥무죽양경화반괴조（32례），경동맥죽양경화반괴조재근거죽양경화반괴성질분위2아조：경동맥죽양경화은정반괴조（30례）화경동맥죽양경화불은정반괴조（34례）。채용전자동생화의검측혈청C-반응단백（CRP）、저밀도지단백담고순（LDL-C）화동형반광안산（Hcy）수평，채용매련면역법（ELISA법）검측혈청OPG수평，병여31례건강대조조진행비교。결과경동맥무죽양경화반괴조、경동맥죽양경화은정반괴조화경동맥죽양경화불은정반괴조혈청CRP、Hcy화OPG수평균명현고우건강대조조（균P＜0.05），경동맥죽양경화은정반괴조혈청OPG수평명현고우경동맥무죽양경화반괴조（P＜0.05），경동맥죽양경화불은정반괴조혈청OPG수평명현고우경동맥죽양경화은정반괴조、경동맥무죽양경화반괴조（P＜0.05）。결론뇌경사환자혈청OPG수평현저승고，병여경동맥죽양경화반괴은정성밀절상관。
Objective To investigate the relationship between serum osteoprotegerin (OPG)and carotid atherosclerotic plaque in patients with cerebral infarction.Methods According to color Doppler assessment,patients with cerebral infarction were classified as having atherosclerotic plaques (plaque group,n=64)or not having atherosclerotic plaques (non-plaque group,n=32).Patients with atheroscle-rotic plaques were further divided into stable plaque group (n=30)and unstable plaque group (n=34). Serum levels of C-reactive protein (CRP),low density lipoprotein cholesterol (LDL-C),homocysteine (Hcy) were measured using automatic biochemical analyzer. Serum levels of OPG were determined by ELISA. The results were compared with healthy controls (control group, n=31).Results Compared with control group,serum levels of CRP,Hcy and OPG significantly increased in non-plaque group, stable plaque group and unstable plaque group (P<0.05).Compared with non-plaque group,serum OPG levels increased in stable plaque group.Compared with stable plaque group or non-plaque group,serum OPG levels increased in unstable plaque group (P<0.05). Conclusion Serum OPG levels significantly inc-rease and are closely related to carotid atherosclerotic plaque stability in patients with cerebral infarction.